儿童胸腺在各种疾病中的改变 Ⅰ.儿童退化胸腺内淋巴细胞的改变——组织学、免疫组化和超微结构研究  

Changes of Children Thymuses in Different Diseases Ⅰ. Changes of Lymphocytes of Involuted Thymuses in Childhood: Histological, Immunohistochemical and Ultrastructural Study

作　　者：梁生本 章敏[1] 李仁[1] 赵振武 王延复 周莉 于东海 

机构地区：[1]哈尔滨医科大学病理学教研室 [2]哈尔滨市红十字儿童医院病理科

出　　处：《哈尔滨医科大学学报》1993年第1期9-12,T080,共5页Journal of Harbin Medical University

摘　　要：本文对70例退化胸腺进行组织学、8种淋巴细胞分化抗原的免疫组织化学以及超徽结构观察。各种疾病均可伴有胸腺退化(TI);感染性疾病时的TI比非感染性疾病更严重;病程与退化程度呈高度正相关。胸腺细胞(Thy-C)数量减少是TI的主要改变之一,但TI时Thy-c的分化顺序和亚群分布并不改变。胸腺髓质内出现淋巴滤泡(LF)可能与自身免疫有关。70 involuted thymuses obtained at autopsy from children died of different diseases were studied with histological, immunohistochemical and ultrastructural approaches. In the immunohistochemical study, monoclonal antibodies against 8 lymhocyte differentiation antigens including CD4, CD8, CD_3, CD1, CD2, CD25, CD22 and T_9 were used. Our findings suggest that thymic involution might occur in different diseases, and the one caused by infectious disease is usually more severe than that caused by non-infectious disease. The longer the course of disease is, the more severe the thymic involution is. The decrease in number of thymocytes is one of main changes of thymic involution. But the differentiation process of thymocytes and the distribution of different subpopulations of T cells in thymus are not changed by thymic involution. There might be some relationship between the lymphoid follicles in thymic medulla and autoimmune diseases.

关 键 词：胸腺 退化 淋巴细胞 超微结构 

分 类 号：R361.3[医药卫生—病理学]