膀胱移行细胞癌胞核 DNA 含量测定及临床意义  

Determination of Nuclear DNA Content in Transitional Cell Carcinoma of the Bladder and Its Clinical Significance

作　　者：于冬梅[1] 柳风轩[1] 朱英桂[1] 闫晓初[1] 李才安[2] 傅晓岚[2] 

机构地区：[1]第三军医大学一院病理科,重庆市630038 [2]第三军医大学一院中心仪器室,重庆市630038

出　　处：《中国肿瘤临床》1993年第2期103-106,F004,共5页Chinese Journal of Clinical Oncology

摘　　要：应用显微分光光度计检测膀耽正常粘膜、膀胱乳头状瘤及膀胱移行细胞癌共23倒(正常粘膜3例、乳头状瘤5例及移行细胞癌15例,移行细胞癌分三级,Ⅰ级、Ⅱ级、Ⅲ各5例),其结果显示,正常粘膜上皮细胞和乳头状瘤细胞核及移行细胞癌细胞核Ⅰ、Ⅱ、Ⅲ各组之间胞核DNA含量均值有显著的差别(P<0.05～0.01)。本文通过检测细胞核DNA含量的变化,作者认为对膀胱移行细胞癌的诊断、移行细胞癌分级及判断预后有参考价值。Microspectrophotometer was used to measure the DNA content of 3 mucosa specimens of normal blad- der, 5 papillomas and 15 bladder transitional cell carcinomas. The transitional cell carcinoma was divided into 3 grades (gradeⅠ, Ⅱ, Ⅲ)and each grade group comprised 5 cases. The result indicated that the significant differences of DNA value were seen between the normal mucosal epidermal cell, papilloma cell and transitional cell carcinoma gradeⅠ, Ⅱand Ⅲ cells(P<0.01 ). The dffference of DNA value between papilloma and transitional cell carcinoma grade I was statistically significant(P<0.05). There was also significant difference among transtional cell carcinoma gradeⅠ, Ⅱand Ⅲ(P<0.05-0.01). The determination of cell nuclear DNA content was helpful in the diagnosis, classification and predicting prognosis of the transitional cell carcinoma of the bladder.

关 键 词：DNA 诊断 预后 膀胱肿瘤 

分 类 号：R737.140.4[医药卫生—肿瘤]