固-液相转移催化C-烷基化反应——2-戊基-环戊酮-2-甲酸乙酯的合成  

SOLID-LIQUID PHASE TRANSFER CATALYTIC C-ALKYLATION——Synthcsis of 2-Pentan-2-Carbethoxycyclopentan-Ⅰ-one

作　　者：杜汝励[1] 阮秀兰[1] 

机构地区：[1]暨南大学化学系

出　　处：《暨南大学学报（自然科学与医学版）》1993年第3期45-49,共5页Journal of Jinan University(Natural Science & Medicine Edition)

摘　　要：2—戊基—环戊酮—2—甲酸乙酯是有机精细化工合成的重要中间体,以环戊酮—2—甲酸乙酯为原料,四丁基溴化铵(TBAB)为相转移催化剂,固体碳酸钾为碱,在固—液相转移催化条件下与正溴戊烷进行C—烷基化反应制得。其反应最佳条件为:COOEt:n-C_5H_(11)Br:K_2CO_3:TBAB(mol)=1:1.2:1.3:0.1以甲苯为溶剂,于80℃反应2小时,产率可达82％～84％。This paper reported the synthcsis of 2-pentan-2-carbcthoxycyclopentan-1-onc and n-bromopentane using solid-liquid phase transfer catalytic condition. Tetrabutylammonium bromide was used as a catalyst, the optimum conditions were:(?)-COOEt:n-C_5H_(11)Br:K_2CO_3:TBAB=1:1.2: 1.3: 0.1 by mol. in solvent toluen, and then reacted at 80℃ for 2 hours, the yields were 82%～84%. The effect of varied factors on the yield of C-alkylation was also discussed.

关 键 词：C-烷基化 甲酸乙酯 相转移催化 

分 类 号：O623.624.1[理学—有机化学]