食管鳞状上皮涂片细胞AgNORs的计量研究  

QUANTITATIVE STUDY ON AgNORs IN ESOPHAGEAL CYTOSMBARS

作　　者：王东煜[1] 项芸岩 沈琼[1] 阎爱华[1] 任秀花[1] 蔡祥生[1] 

机构地区：[1]河南医科大学癌前期研究室,河南省鹤壁市肿瘤防治研究所

出　　处：《癌症》1994年第1期26-28,共3页Chinese Journal of Cancer

摘　　要：应用银染技术对１０５例食管拉网涂片细胞进行了ＡｇＮＯＲｓ计量研究。检测结果：正常底层细胞ＡｇＮＯＲｓ均数（３．０８）多于正常中层细胞（２．３７）。随增生和病变级别增高，ＡｇＮＯＲｓ均数逐级增高：轻度增生、重度增生Ⅰ级、重度增生Ⅱ级、近癌和鳞癌细胞分别为３．６１、４．６９、５．６４、６．６４和８．０６（Ｐ＜０．０１）。证明ＡｇＮＯＲｓ是一种反映细胞增殖水平的较敏感的指标；食管上皮细胞学增生分级方法是合理可靠的，它反映了不同级别细胞增殖水平的改变。The argyrophilic proteins, associated with nucleouls olganizer regions(Ag-NORs)of esophageal cy tosmears from l05 cases were analyzed by argyophilic method Theresults sho wed that the mean number of AgNORs per nucleus in normal epithelia cells ofbasal layer(3.08)was more than that in the normal intermediate cells(2.37).These para-meters also graduallv increased in hyperplasia(3.61),sever dysplasia grade Ⅰ(4.69),severdysplasia grade Ⅱ(5.64) near-carcinoma( 6.64)and squamuos carcinoma cells(8.06).theAgNORs increase parallel to The severity of the disease(P<0.01).It is suggested that Ag-NORs is a comparatively sensitive index to reflect the ploliferative iever of cells. These resu-Its indicate that the classification method of esophageal cytolgy is reliable and reflect thelever of proliferation of different grade cells as well.

关 键 词：食管 细胞学 AGNOR染色 癌前状态 

分 类 号：R735.102[医药卫生—肿瘤]