重组人粒系集落刺激因子对白血病细胞的作用  

EFFECTS OF RECOMBINANT HUMAN GRANULOCYTE COLONY-STIMULATING FACTOR ON LBUKEMIC CELLS

作　　者：黄非[1] 赵惠平[1] 高雪芝[1] 戴梅美[1] 范蕾蕾[1] 

机构地区：[1]镇江医学院附属医院血液科,南京铁道医学院

出　　处：《癌症》1994年第1期29-31,34,共4页Chinese Journal of Cancer

摘　　要：作者观察了重组人粒系集落刺激因子（ｒｈＧ－ＣＳＦ）对ＨＬ一６Ｏ细胞和原代培养的急性髓系白血病（ＡＭＬ）细胞的作用，结果显示，ｒｈＧ一ＣＳＦ可刺激白血病细胞生长，并诱导部分ＡＭＬ细胞向粒系分化。提示ｒｈＧ一ＣＳＦ对白血病细胞存在着增殖与分化的双重作用，这种作用对改进白血病治疗可能产生重要影响。The effects of recombinant human G-CSF(rhG-CSF)on proliferation anddifferentiation of HL-60 cells and primacy cultured hunian acute myeloblastic leukemia(AML)cells in vitro were investigated,Our data showed that rhG-CSF stimulated the growth of leu-kemic cells and induced granulocytic differentiation of AML cell in 6/ll cases after 6-dayculture.This differentiation was accompanied by morphological, nitroblue tetrazolium(NBT)reduction activity and cy tochemical evluence.The results obtained in this sludy indicate thatrhG-CSF may have the dual action of proliferation and differenti ation on leukemic cells whichwould produce important influence to improve the tleatment of leukemia

关 键 词：粒系 集落刺激因子 白血病 细胞 

分 类 号：R733.705[医药卫生—肿瘤]