醋酸铅、氯化汞对小鼠精子染色体畸变及其受精卵发育的影响  

EFFECTS OF LEAD ACETIC AND MERCURIC AHLORIDEON CHROMOSOMES0F SPERMATOZOA ANDDEVELOPMENT OF ZYGOTES FROM MICE

作　　者：李庶良 李修山 于永强[1] 邵华[1] 高敏[1] 张秀珍[1] 

机构地区：[1]青岛化工职防院,青岛化工部劳动保护研究所

出　　处：《癌变．畸变．突变》1994年第5期14-16,共3页Carcinogenesis,Teratogenesis & Mutagenesis

摘　　要：分别用醋酸铅（１ｍｇ／ｋｇ·ｗｔ）和氯化汞（Ｏ．５ｍｇ／ｋｇ·ｗｔ）给雄性性成熟昆明种小鼠染毒，共染毒７０天，然后用染毒雄性小鼠与非染毒雌性小鼠交配，取受精卵观察卵发育状况并制备受精卵染色体。结果表明，醋酸铅染毒组（２６．８％）和氯化汞染毒组（３６．４％）受精卵发育异常率，均明显高于非染毒组（１３．３％）（Ｐ＜０．０１）。两组精子染色体数目异常率（１１．９８％和１０．８０％）也高于非染毒组（８．６３％）。但无统计学差异（Ｐ＜０．０５）。Male mice were administered by lead acetic(1mg/kg·wt)and mercuricchloride(0.5mg/kg· wt)for 70 days。The males were mated with females non一exposed.Females were killed.The zygotes of oviduct were flushed out and the zygotes abserved andtheir chromosomes prepared. The results Showed that rats(26.8%,36.4%)of abnormalities of the zygotes for lead acetic and mercuric chloride groups are higher thancontrol group(13.3%)(P<0.01,P<0.01)and that rates(11.98%,10.80%)of zygotesfor abnormalities of male chromosome counts in exposed mice are also higher than incontrol.

关 键 词：醋酸铅 氯化汞 精子 染色体畸变 受精卵 

分 类 号：Q319.31[生物学—遗传学] R135.1[医药卫生—劳动卫生]