小鼠移植性肿瘤血清中γ－GT和α1—AT活性的检测  

DETERMINATION OF γ-GT AND α1-AT ACTIVITIES IN SERUM OF MOUSE WHTH TRANSPLANT ABLE TUMOR

作　　者：李亢宗[1] 魏亚明[1] 朱昕[1] 

机构地区：[1]兰州医学院生化教研室,兰州医学院第一附属医院

出　　处：《癌症》1994年第4期312-313,共2页Chinese Journal of Cancer

摘　　要：本文测定了ＨｅＰＡ与Ｓ１８０小鼠血清中γ－６Ｔ和α１—ＡＴ活性。γ－６Ｔ活性：正常鼠为１９．３３±４．８７ｍＩＵ／ｍｌ；移植第５及第１０天Ｓ１８０的值分别为１０．３２±３．９０，９．７８±２．８６ｍＩＵ／ｍｌ；第５及第１０天ＨｅｐＡ的值分别为１３．１５±３．１７，１１．８１±２．７５ｍＩＵ／ｍｌ，均比正常鼠显著降低（Ｐ＜０．００１）。α１—ＡＴ活性：正常鼠每分钟为１．９２７±０．１８５μｍｏｌ／ｍｌ，移植第５及策１０天Ｓ１８０的值每分钟分别为１．５７５±０．２０４μｍｏｌ／ｍｌ，１．４１２±０．２１７μｍｏｌ／ｍｌ；第５及第１０天ＨｅｐＡ的值每分钟分别为１．３８７±０．２４４，１．１７９±０．１７９μｍｏｌ／ｍｌ，均比正常降低（Ｐ＜０．００１）。肿瘤病程与γ—ＧＴ，α１—ＡＴ活性呈负相关。The changes of γ-GT and α1-AT activities in serum were examined during the different period of transplantation of hepatoma and S180 in mice.All serum activities of eitherα1-AT or γ-GT, in mice bearing hepatoma or S180 at 5 and 10 days decreased significantly(P<0.001).It suggested that the two enzymes level decrease gradually with the development of the transplanted tumor.

关 键 词：谷氨酰转肽酶 蛋白酶 移植性 肿瘤 

分 类 号：R73－352[医药卫生—肿瘤]