检测粪便中的癌相关抗原S－Tn，Tn及CEA诊断胃癌──免疫电泳法  

DIAGNOSIS OF GASTRIC CANCER BY DETECTION TUMOR-ASSOCIATED ANTIGEN S-TN,TN,AND IN FFCES

作　　者：袁玫[1] 张晓平[1] 李力[1] 李华[1] 万军[1] 

机构地区：[1]北京解放军总医院肿瘤研究室

出　　处：《癌症》1994年第5期405-407,共3页Chinese Journal of Cancer

摘　　要：以两株单克隆抗体，ＧＳ－２及ＣＬ－３组合，用免疫电泳法检测粪便提取液中的癌相关抗原Ｓ－Ｔｎ，Ｔｎ及ＣＥＡ，检测的病例为胃癌７５例，直结肠癌６６例、胰腺癌８例，浅表性胃炎７例，萎缩性胃炎１５例，胃及十二指肠溃疡病２０例，胆囊结石１０例以及正常人１００例。结果表明：ＧＳ－２检测各组阳性率为：胃癌８０％，结肠癌５８．７％，胰腺癌１２．５％，正常人为９％，非恶性病变组０～１５％。ＣＬ－３检测各组阳性率为：胃癌７７．３％，结肠癌６０．６％，胰腺癌７５％，正常人组５％，非恶性病变５－１４２％，上两株单抗组合检测，胃癌阳性率提高到９４．５％，肠癌为８６．４％，正常人组１２％，非癌组为１７．３％。Using two monoclonal antibodies, GS-2 and CL-3,tumor-asso-Ciated antigens S-Tn,Tn,and CEA were assayed by electropnoresis in fecal extractsfrom patients with gastric cancer (75cases), colorectal cancer (66 cases), pancreaticcancer(8 cases),gastritis ( 22 cases), ulcers (20 case), polyps (2 cases), cholecystolith-iasis (10 cases),and normal individuals (100 cases). The results indicated that: 1. When detected by GS-2, the positive rates were :gastric cancer 80%, colorectalcancer 58.7%, pancreatic cancer l.5%nomal individuals 9%, and non-malignant dise-ases 0-15%.2.When detected by CL-3,the positive rates were:gastric cancer 77.3%,colorectalcancer 60.6%, pancreatic cancer 68.7%, nomrmal inddividuals 5%, and non-malig-nant diseases 5-l4.2 3. When detected by cocklail of these two antibedies the positive rates were:gastric cancer 94.5%, colorectal cancer 84.6%, normal individuals l2% and non.malignant diseas l7.3% 4. Detection of tumor-associated antigen Tn,S-Tn. and CEA in feces by electropho-resis methods is useful for. the diagnosis of gastric cancer.

关 键 词：癌 相关抗原 单克隆抗体 诊断 胃肿癌 

分 类 号：R735.204[医药卫生—肿瘤]