肽6A与RGDS肽对大鼠颈总动脉血栓形成的影响  

EFFECT OF PEPTIDE 6A AND RGDS PEPTIDE ON RAT CAROTIC ARTERY THROMBOSIS

作　　者：姚兴海[1] 付爱华[1] 汤健[1] 唐朝枢[1] 赵明[1] 彭师奇[1] 朱国英[1] 王秉瑞[1] 吴祥林[1] 

机构地区：[1]北京医科大学心肺内分泌研究室,北京医科大学天然药物与仿生药物国家重点实验室,北京医科大学第一医院心内科,卫生部兰州生物制品研究所

出　　处：《北京医科大学学报》1994年第1期17-19,共3页Journal of Peking University(Health Sciences)

摘　　要：在２０％ＦｅＣｌ３造成大鼠颈总动脉血栓形成的模型上，分别预防（血栓形成前）和治疗（血栓形成后）应用合成的纤维蛋白（原）降解肽片段，肽６Ａ（５０μｍｏｌ／ｋｇ）和ＲＧＤＳ（１０μｍｏｌ／ｋｇ）或联合肽６Ａ（２５μｍｏｌ／ｋｇ）与ＲＧＤＳ（５μｍｏｌ／ｋｇ）静脉滴注，明显抑制动物的血栓形成，使血浆和血管组织ｃＧＭＰ含量明显增加，肽６Ａ还明显降低血浆纤维蛋白原含量。本工作为肽６Ａ和ＲＧＤＳ作为新型血管再通剂提供了实验依据。n the model of rat carotid thrombosis induced by 20% FeCl3,fibrin (ogen) degradation product peptide 6A (50 μ mol/kg),RGDS (10μmol/kg),and peptide 6A (25μmol/kg)plus RGDS(5 μ mol/ kg)were intravenously infused for prevention(before thrombosis)and treatment(after thrombosis)respectively.It was found that the thrombosis was significantly suppressed,plasma and vascular cGMP content was obviously increased,and that peptide 6A markedly lowered plasma fibrinogen content.The results afford experimental evidence of peptide 6A and RGDS as novel agent of vascular recanaliza-tion

关 键 词：肽6A RGDS肽 纤维蛋白原 血栓形成 

分 类 号：R364.15[医药卫生—病理学]