羟自由基对人工平板膜损伤作用的研究  

THE STUDY OF DAMAGING ACTION OFHYDROXYL RADICAL ON ARTIFICAL PLANAR MEMBRANE

作　　者：栗刚[1] 张川里[1] 吴本[1] 

机构地区：[1]北京医科大学生物物理学系

出　　处：《北京医科大学学报》1994年第6期444-446,共3页Journal of Peking University(Health Sciences)

摘　　要：用人工平板膜模型系统研究了羟自由基对人工膜的损伤作用和羟自由基清除剂─—苯甲酸钠的保护作用。ＥＤＴＡ和ＦｅＳＯ４的羟自由基生成系统对人工膜的损伤作用有二种表现形式，一是在短时间内造成膜破裂；二是造成膜电阻率和膜击穿电压的明显下降。苯甲酸钠的保护作用表现为使膜维持时间、膜电阻率和膜击穿电压基本恢复正常。The damaged action by hydroxyl radical on the artificial membrane and the protection of hydroxyl radical scavenger-sodium benzoate were studied with the model system of artificial membrane .Therewere two forms in damaged action by hydroxyl radical system;the one one was membrane break in short time;and the other was obvious decrease in membrane resisitivity and break-down voltage.The protec-tion of sodium benzoate showed that they basically recovered to normal level in membrane maintaining time,resisitivity and break-down voltage.

关 键 词：人工平板膜 羟自由基 苯甲酸纳 

分 类 号：R363.2[医药卫生—病理学] R965.2[医药卫生—基础医学]