P53蛋白在子宫颈癌中的高表达  

Overexpression of P53Protein in Human Cervical Carcinoma

作　　者：李惠芳[1,2,3] 杨予石 连卫民[1,2,3] 张娜[1,2,3] 刘人秋 毕桂英[1,2,3] 贾宗智 杨书敏 李青 王崇宇 

机构地区：[1]生物化学教研室 [2]病理学教研室 [3]阳泉市第一人民医院

出　　处：《长治医学院学报》1994年第4期286-288,共3页Journal of Changzhi Medical College

摘　　要：利用免疫组织化学方法，对３９例子宫颈癌（５例原位癌。３例早期浸润癌，３１例浸润癌）组织石腊包理标本进行了Ｐ５３表达的检测，结果发现３９例子宫颈癌标本中．１９例有Ｐ５３的高表达（４８．７％）（２例原位癌、且例早期浸润癌、１６例浸润癌）。还发现Ｐ５３高表达阳性率在分化较好的浸润癌相对较低（４２．９％），在分化较差的浸润癌相对较高（７５％）。这些结果表明Ｐ５３的高表达在子宫颈癌的发生中是一个比较常见的基因改变，Ｐ５３高表达的阳性率与子宫颈癌的分化程度有关。In normal cells, p53 protei n is virtually unndetectable by immunohistochemical mathcds. Mutation of p53 gene results in overexpression of the protein and thus levels of p53 detectable by immunohistochemical methods. We studied the expression of p53 protein in humanCervical carcinoma (39 cases )paraffin embedded tissue sections by immunohistochemical methods.Of these cervical carcinorna specimens overexpression of P53 protein was showed in 19 cases (48.7 % )and was a higher percentage in low differentiation rodent cancer (75 % ) than in high differentiation rodent cancer (42. 9 % ). These results suggested that overexpression of p53 often occuredin cervical carcinoma and that the percentage of overexpression of p53 Was tight relative to thedifferentiation degree of human cervical carcinoma.

关 键 词：P53蛋白 子宫颈癌 免疫组织化学 子宫肿瘤 

分 类 号：R737.330.2[医药卫生—肿瘤]