幽门螺杆菌感染与胃粘膜上皮异型增生的关系  

RELATIONSHIP OF HELICOBACTER PYLORI INEECTION AND EPITHELIAL DYSPLASIA OF THE STOMACH

作　　者：张旭晨[1] 赵凤忘 鲁香凤[1] 

机构地区：[1]北京东直门医院病理科

出　　处：《承德医学院学报》1994年第2期84-87,共4页Journal of Chengde Medical University

摘　　要：观察６６例慢性萎缩性胃炎伴异型增生的胃粘膜活检标本的幽门螺杆菌感染情况。结果：慢性活动性萎缩性胃炎的感染率显著高于慢性静止性萎缩性胃炎（Ｐ＜０．００５），各级异型增生间的感染率无差别（Ｐ＞０．０５），慢性活动性萎缩性胃炎伴轻、中度异型增生者显著高于慢性静止性茎缩性胃炎（Ｐ＜０．００５）。认为：ＨＰ感染与胃粘膜上皮异型增生有密切关系，其感染引起胃癌发生的可能过程为幽门螺杆菌感染正常胃粘膜→急性胃炎→慢性浅表性胃炎→慢性萎缩性胃炎→异型增生→胃癌。Gastroendoscopic biopsy specimins of chronic a trophic gastritis with dysplasia were observed.The results showed that the prevalence of Helicobacter pyloriinfection in patients with chronic active atrophic gastritis(CAAG)were significantly higher than that in patients with chronic stable atrophic stable atrophic gastritis(CSAG).The prevalence among dysplasias had no statistically significant difference.The mild and moderate degree dysplasia more often occurred in CAAG than in CSAG.It is suggested that Helicobacter pylori infection is closely associated with the pathogenesis of epithelial dysplasia of the stomach.The probable procddures of Helicobacter pylori to cause gastric cancer are:gastric mucosa infected by Helicobacter pylori→acute gastritis→chronic superficial gastritis→chronic atrophic gastritis→dysplasia→gastric cancer.

关 键 词：幽门螺杆菌 胃肿瘤 癌前状态 

分 类 号：R735.202[医药卫生—肿瘤]