慢性粒细胞白血病原始细胞危象细胞分化抗原的检测  

Assay of Cell Differentiation Antigens in Chronic Myeloid Leukaemia in Blast Crisis

作　　者：韩凤来[1] 许燕群[1] 严舫[1] 温伟荣[1] 

机构地区：[1]第二军医大学长海医院血液内科

出　　处：《第二军医大学学报》1994年第2期169-172,共4页Academic Journal of Second Military Medical University

摘　　要：作者在细胞形态学、细胞化学诊断的基础上，采用一组单克隆抗体检测了８例ＣＭＬ－ＢＣ白血病性原始细胞分化抗原的表达特征。结果显示：３／８例ＰＯＸ反应阳性、形态学诊断ＣＭＬ－急粒变病例、免疫学检测呈现粒、单系抗体（ＨＩＭ５ＨＩ９８）的阳性反应，两者之间具有较好的一致性。而５／８例ＰＯＸ反应阴性，ＰＡＳ呈阳性的病例，形态学与免疫学诊断两者之间存在较大的差异，８例均无Ｔ细胞和巨核系抗原的表达。The cell differentiation antigens were assaied by a panel of monoclonal antibodies based on cell morphological and chemical staining in 8 cases of chronic myeloid leukaemia in blast crisis (CML-BC). The results showed that 3/8 cases of CML-acute myeloid translation with POX positive reaction had positive characteristics of myeloid-mono series antibodies (HIM5, HI98) but there were rather big difference between morphology and immunology diagnosis in 518 cases in which POX reaction was negative. In 8 cases there were no T-cell and megakaryocytic series antigens reaction.

关 键 词：白血病 原始细胞 细胞分化 抗原 

分 类 号：R733.720.4[医药卫生—肿瘤]