人肝RNA对辐射诱发小鼠骨髓细胞染色体损伤的防护作用  

STUDIES ON PROTECTIVE EFFECTS OF HUMAN LIVER RNA ON CHROMOSOME DAMAGE OF MOUSE BONE MARROW CELLS INDUCED BY TRRADIATION

作　　者：丛宪玲[1] 王献理[1] 舒晴[1] 

机构地区：[1]白求恩医科大学预防医学院

出　　处：《辐射研究与辐射工艺学报》1994年第3期174-178,共5页Journal of Radiation Research and Radiation Processing

摘　　要：以昆明种雄鼠为模型，皮下注射不同剂量的人肝ＲＮＡ，随后１、５ＧｙＸ射线全身照射，照射后７ｈ和２４ｈ检测骨髓细胞染色体畸变。结果表明，人肝ＲＮＡ本身不诱发小鼠骨髓细胞染色体畸变；照射前不同时间给予人肝ＲＮＡ，对辐射诱发的骨髓细胞染色体畸变的降低作用以照射前２４ｈ给药最佳；照射前２４ｈ给予不同剂量的人肝ＲＮＡ，都可不同程度地降低Ｘ射线诱发的骨髓细胞染色体畸变，其中以２５ｍｇ／ｋｇ剂量组降低作用最显著。Male mice were hypodermically injected with human liver RNA.then exposed to 1 .5 Gy X-radiation 7 hours or 24 hours later, the bone marrow cells were tested using the method of chromosome aberration. The results showed that human liver RNA could significantly reduce the frequencies of chromosome aberrations in bone marrow cells of mice 7 hours after exposed to 1 .5 Gy X-rdiation. The best injection time of human liver RNA was 24 hours prior to irradiation and the best dose was 25 mg/kg. 25 mg/kg human liver RNA could also reduce the frequencies of chromosome aberrations in mice 24 hours after exposed to 1 .5 Gy X-radiation. This function might be related to interferons induced by injection of human liver RNA.

关 键 词：电离辐射 染色体畸变 双链核酸 

分 类 号：R811.5[医药卫生—放射医学]