乙苯吸入毒性研究  

INHALATION TOXICITY OF ETHYLBENZENE

作　　者：曾昭慧[1] 邓海[1] 杨柯[1] 黄明芳[1] 王志爽[1] 吕伯钦[1] 

机构地区：[1]中国预防医学科学院劳动卫生与职业病研究所

出　　处：《工业卫生与职业病》1994年第6期354-356,共3页Industrial Health and Occupational Diseases

摘　　要：急性吸入毒性研究表明，乙苯对大鼠ＬＣ５０为３３．０（２７．４～３８．６）ｍｇ／Ｌ；浓度４．８ｍｇ／Ｌ时家兔出现轻度呼吸道和眼刺激，７．３ｍｇ／Ｌ时见到显刺激，在亚急性吸入毒性实验中，在１０２７．９ｍｇ／ｍ＾３组中枢神经阈下冲动综合能力明显增加；肝功和血液学检查未见改变，低浓度５８ｍｇ／ｍ＾３也未见指标的，结合ИＢＡＨＯＢ的研究报道认为乙苯的无作用浓度可能为＜１００、＞５８ｍｇ／ｍ＾３。Studies on acute toxicity of ethylbenzene indicated that the 2-hr LC_(50) in male rat was 33mg/L.Unsteady gait,poor coordination,tremor and hyponea were observed in acutely intoxicated rats.Marked irritation of mucous membrane of upper airway and eyes was noted in rabbits exposed to ethylbenzene at concentration of 7.3mg/L,but no irritation was found at exposure of 2.3mg/L.In subacute toxicity experiment,the summation capacity of the central nervous system was in creased in rats exposed to high concentration(1027.9mg/M3,but there was no change in liver function test and histopathological studies. No adverse effect level may be(100) 58mg/m￣3,from this study and the study of NRAHOB.

关 键 词：苯中毒 毒性 急性吸入毒性 乙苯 吸入毒性 

分 类 号：R135.12[医药卫生—劳动卫生]