^（99m）Tc－MDP放化纯测定法的改进  

Improvement on the method for determining radiochemical purity of ￣(99m)Tc-MDP

作　　者：黄天森[1] 吴卫国[1] 蒋红珠 

机构地区：[1]上海市药品检验所

出　　处：《核技术》1994年第5期301-303,共3页Nuclear Techniques

摘　　要：采用纸层析方法，以０．９％氯化钠（Ⅰ）和８５％甲醇（Ⅱ）为两个展开剂系统，测定了９９ｍＴｃ、９９ｍＴｃ－胶体和９９ｍＴｃ－ＭＤＰ的Ｒｆ值。其Ｒｆ值在Ⅰ中分别为０．６８—０．７６、０和１．０；在Ⅱ中分别为０．６－０．７、０和０．结果表明，用Ⅰ可将９９ｍＴｃ－胶体与９９ｍＴｃ和９９ｍＴｃ－ＭＤＰ分离；用Ⅱ可将９９ｍＴｃ与９９ｍＴｃ－胶体和９９ｍＴｃ－ＭＤＰ分离．条件试验的结果表明，在两个系统中选择新华一号滤纸为载体，并在Ⅰ中采用氮压下展层的方法，可用以测定９９ｍＴｃ－ＭＤＰ的放化纯，其方法简便、可行、有效。By paper chromatagraphy method, taking 0.9% Nacl(System Ⅰ) and 85%methanol (System Ⅱ) as two developing solvent systems, the Rf values of 99mTc,99mTc- colloid and 99mTc- MDP were determined.They are respectively 0.68-0.76,0 and 1.0 in System Ⅰ; 0.6-0.7, 0 and 0 in System Ⅱ.This result indicates 99mTc-colloid can be separated from 99mTc and 99mTc-MDP with SystemⅠ;99mTc separated from 99mTc-colloid and 99mTc-MDP with System Ⅱ. The result indicates the radiochemical purity of 99mTc-MDP can be determined by the two developingsolvent systems and developing under nitrogen pressure in SystemⅠ.The method is convenient,feasible and effective.

关 键 词：纸层析 锝99m-MDP 放化纯度 测定 

分 类 号：R817.9[医药卫生—影像医学与核医学]