煤焦沥青烟气吸入诱发小鼠前胃肿瘤的研究  

STUDY ON THE INDUCTION OF FORESTOMACH NEOPLASM IN MICE BY INHALATION OF COAL TAR PITCH SMOKE

作　　者：王江[1] 赵庆夏[1] 魏丽[1] 李新荣[1] 张红新[1] 

机构地区：[1]河南医科大学病理解剖学教研室

出　　处：《河南医学研究》1994年第2期97-103,共7页Henan Medical Research

摘　　要：本研究选用封闭群昆明种小鼠１００只，将其随机分为两组（Ａ、Ｂ组），每组５０只。Ａ组小鼠每天在一密闭柜中暴露于煤焦沥青烟气３ｈ。柜内烟气和苯并［ａ］芘平均浓度分别为１６５．５０ｍｇ／ｍ３和１９．５０μｇ／ｍ３。实验共持续８个月，其中前４个月为沥青烟气吸入期，后４个月为观察期。Ｂ组为对照组。整个实验中Ａ组共发现２９例小鼠前胃肿瘤，发生率为７２．５０％（２９／４０）。其中有７例为鳞状细胞癌（２４．１４％），其余为鳞状细胞乳头状瘤。病理检查显示，由煤焦沥青烟气诱发的小鼠前胃肿瘤的发生遵循由上皮增生到乳头状瘤，再癌变的规律。本研究结果提示，煤焦沥青烟气不仅有致肺和皮肤癌作用，还可能是诱发食管癌的危险因子。n this study,100 closed colony Kunming mice were used and divided randomly into two groups(group A and B).Each group had 50 mice.The mice in group A were exposed to coal tar pitch smoke(CTPS)in a sealed box 3 hours a day.The average concentrations of CTPS and B[a]Pin the box were 165.50mg/m3 and 19.50μg/m3 respectively.The experiment lasted for 8 months,and the first 4 months,the animals were treated by inhilathion of CTPS,and the other 4months,the mice were raised for observations, Group B was designed as control. The forestomach neoplasms were found in 29 mice in group A throughout the experiment,and the incidence rate was 72.50%(29/40).There were 7 squamous cell carcinomas among them(24.14%)and the rest,squa-mous cell papillomas.The pathological examinations showed that the occurence of forestomach neo-plasms induced by CTPS followed the role that the lesions began with epithelial hyperplasia,then to papilloma,at last,carcinoma. There were extensive invasion and metastases in the carcinon1as.The results in this study suggest that CTPS not only has carcinogenic effect to the lung and skin,but also would be a risk factor to the neoplasms in the digestive tract.

关 键 词：沥青烟气 前胃肿瘤 病理学 胃肿瘤 

分 类 号：R735.202[医药卫生—肿瘤]