肺癌细胞雌激素受体和孕激素受体的研究  

Estrogen and Progesterone Receptors in Lung Cancer Cells

作　　者：孙广平[1] 郭洪涛[1] 苏振邦[1] 张灿宇[1] 杨鲲鹏[1] 吉庆春[1] 卢欣萍 

机构地区：[1]河南医科大学二附院,河南医科大学一附院,中山医科大学三附院胸外科

出　　处：《河南肿瘤学杂志》1994年第2期88-90,共3页Henan Journal of Oncology

摘　　要：应用酶联亲和组化法，对４４例手术切除的新鲜肺癌标本和１５例远离癌灶正常肺组织的雌激素受体（ＥＲ）和孕激素受体（ＰＲ）进行了检测。结果表明：肺癌的ＥＲ阳性率为５９．１％，ＰＲ阳性率为５６．８％，远离癌灶的正常肺组织中ＥＲ阳性率为４０％，ＰＲ阳性率为３３．３％，证明部分肺癌细胞中确有ＥＲ、ＰＲ存在；肺癌细胞中ＥＲ、ＰＲ阳性事与组织学分级有明显关系，与肺癌的病理类型、临床分期以及患者性别、年龄无关。我们认为部分肺癌组织中存在有ＥＲ、ＰＲ，为选择性应用内分泌疗法治疗肺癌提供了理论依据。The estrogen receptors (ER) and progesterone receptors (PR ) from 44 fresh resectedspecimens of lung cancer and 15 normal lung tissues which were far from the cancer focuswere measured by using enzyme-linking affinity and immunohistochemistry method. The results showed that:the positive rates of ER and PR in the lung cancer cells were 59. 1 % (26/44 ) and 56. 8% (25/44), whereas those in the paraneoplasm normal lung tissues were 40%(6/15)and 33. 3 % (5/15),the positive rates of ER and PR were related to the histopathologicgrade of lung cancer cells (P<0. 05), but not related to the pathologic classification of tumors, clinical stages and the patient' S sex and age (P>0. 05). There was much closer relationship between ER and PR (P<0. 005). This study suggests that the presence of ER andPR in the lung cancer cells may provide a basis for juvant endocrine therapy in the selectedlung cancer patients.

关 键 词：雌激素 受体 肺肿瘤 孕激素 

分 类 号：R734.2[医药卫生—肿瘤]