煤焦沥青碘油溶液气管注入诱发大鼠肺癌的实验研究  

Experimpntal Study on Rat Lung Cancer Induced by Intratracheal Instillation of Coal Tar Pitch in Iodized Oil

作　　者：郭柯[1] 赵庆夏[1] 李新荣[1] 魏丽[1] 张宏新[1] 冯志伟[1] 陈琛[1] 任朝胜[1] 

机构地区：[1]河南医科大学病理学教研室,河南医科大学卫生毒理教研室,河南医科大学人体解剖教研室

出　　处：《河南肿瘤学杂志》1994年第4期249-251,共3页Henan Journal of Oncology

摘　　要：本文报告了应用煤焦沥青碘油溶液气管注入诱发大鼠肺癌的实验研究。Ｗｉｓｔａｒ大鼠气管注入致癌物，于实验结束时，肺癌发生率达９１．６％。碘油对照组未见肺癌发生。所诱发的肺癌大多为多灶性起源。最早出现于实验的第１６天，组织学类型有鳞癌、腺癌及腺鳞癌。结果表明：碘油作为赋形剂进行沥青实验性肺癌研究，可提高肺癌发生率，发癌时间提前，中央型肺癌增多且便于Ｘ线观察。This paper presents an experimental study on inducing rat,lung cancer by coal tar pitch in iodized oil instillated intratracheally. Wistar rat was given the carcinogen and at the end of the experiment,the incidence rate of lung cancer was 91. 6%. There was no one case of lung cancer occurring in control group. The most induced lung cancer had multiple focus origin and the earliest case occurred on the 16th day from the beginning of the experiment. The histological types of lung cancer consisted of squamous cell carcinoma,adenocarcinoma and combined squamous-adenocarcinoma. The result showed that when the vehicle of iodized oil was used in inducing lung cancer,the incidence rate of lung cancer was increased F cancer occars earlier; the hilar type of pulmonary carcinoma would be increased in number and be easier for X-ray examination.

关 键 词：煤焦沥青 碘油 肺肿瘤 

分 类 号：R734.202[医药卫生—肿瘤]