钾对在体灌流鼠肺动脉压及肺血管反应性的影响  

The Effects of Potassium on Rat Pulmonary Arterial Pressure and Pulmanary Vascular Reactivity in Situ

作　　者：冯大明[1] 王迪浔[1] 

机构地区：[1]同济医科大学病理生理学教研室

出　　处：《衡阳医学院学报》1994年第1期12-15,共4页

摘　　要：本文采用大鼠在体肺灌流方法，观察了钾对肺动脉压及肺血管反应性的影响。当灌流液中的ＫＣｌ浓度增至６ｍｍｏｌ·Ｌ－１时，肺动脉压无明显变化，增至９～１５ｍｍｏｌ·Ｌ－１范围内，肺动脉压呈剂量依赖性升高。以６ｍｍｏｌ·Ｌ－１ＫＣｌ灌流鼠肺，能完全消除０．０５μｇ白三烯引起的肺血管收缩反应；也能使１０ｕｇ去甲肾上腺素引起的肺动脉压升高百分率由４０±６％降低到２５±４％（Ｐ＜０．０１）；使０．１μｇ血管紧张素Ⅱ所致的肺动脉压升高百分率由２５±４％降至１３±３％The effects of potassium on the pulmonary arterial pressure (Ppa) and pulmonary vascular reactivity were studied by perfusing different doses of KC1(6,9,12, 15mmol/L)in rat lung in vivo. A dose- dependent rise of Ppa was observed from 9 to 15 mmol/L of KC1,but it remained no change in 6 mmol/L of KC1.After KC1 pretreatment (6 mmol/L),pulmonary vasopressor response induced by 0.05μg LTC4 was completely abolished and the increasing percentages of Ppa induced both by noradrenaline (10μg) and by angiotensin (0.1ug) were declined from 40±6% to 25±4% (P<0.01) and from 25±4% to 13±3% (P<0.01).

关 键 词：钾 肺动脉压 血管反应性 白三烯 

分 类 号：R363[医药卫生—病理学]