大鼠旁巨细胞外侧核微量注射利多卡因、L－谷氨酸钠的呼吸、血压效应  

Effect of Microinjection of Lidocaine and L-glutamate into the Nucleus Paragigantocellularis Lateralis on the Respiration and Arterial Blood Pressure in the Rat

作　　者：汪文[1] 郑煜[1] 徐美丽 

机构地区：[1]第二军医大学

出　　处：《华西医科大学学报》1994年第3期266-270,共5页Journal of West China University of Medical Sciences

基　　金：国家自然科学基金

摘　　要：作者研究了在大鼠一侧旁巨细胞外侧核（ＰＧＣＬ）尾侧半微量注射化学阻滞剂利多卡因（Ｌｉｄ）和化学兴奋剂Ｌ－谷氨酸钠（Ｌ－Ｇｌｕ）对呼吸和血压的影响。注射Ｌｉｄ使呼气时程（Ｔｅ）缩短，呼吸频率（ＲＦ）增加，膈肌小片肌电积分峰幅度降低，平均动脉压（ＭＢＰ）下降。注射Ｌ－Ｇｌｕ使吸气时程（Ｔｉ）和Ｔｅ均缩短，ＭＢＰ升高。这些结果表明ＰＧＣＬ尾侧半参与调控呼吸时程、样式、节律和深度，并含有加压结构，参与维持正常动脉血压。The experiments were carried out tostudy the effects of unilateral microinjection of lido-caine(Lid) and L-glutamate(L-glu) into the caudalpart of the nucleus paragigantocellularis lateralis(PGCL) on the respiration and arterial blood pressurein the rat. Injection of Lid reduced the duration of ex-piration(Te),increased the respiratory frequency(RF),and decreased the peak amplitude of the elec-tromyographc activity of the diapbragm and the meanarterial blood pressure(MBP).Injection of L-glu de-creased the duration of inspiration(Ti) and Te and in-creased MBP。 These results suggest that the caudalpart of PGCL participates in the control of the dura-tion, pattern, rhythm and depth of respiration and inthe maintenance of normal arterial blood pressure。

关 键 词：利多卡因 谷氨酸钠 呼吸 血压 

分 类 号：R338.26[医药卫生—人体生理学]