抗瘤酮衍生物的合成和抗S-180活性  

THE SYNTHESES OF THE DERIVATIVES OF NEOPLASTON A10 AND THEIR ANTITUMOR ACTIVITY AGAINST S-180

作　　者：鄢明[1] 李正化[1] 胥佩菱[1] 

机构地区：[1]华西医科大学药学院

出　　处：《华西药学杂志》1994年第3期137-141,共5页West China Journal of Pharmaceutical Sciences

摘　　要：本文报道14个抗癌酮A10的衍生物的合成和抗S-180瘤株的活性,其中有两个化合物(T_(1-6)T_(1-2))抑瘤率与抗瘤酮A10的相当或较高,比阿霉素的为低.除T_(1-2)外,其它均为未知物.Antineoplaston A10 (3-phenylacetylamino-2, 6-piperidinedione) had been isolated from human urine, and possessed more potential antineopl-astic activity and less toxicity. This paper reported that 14 derivatives of antincoplagton A10 had been synthesized. Their chemical structural formulas had been examined and confirmed by elemental analysis. IR, H'NMR and MASS spectrum analysis. There were 13 compo- unds had not been found in the literature (except T1-2)The antineoplastic activity studies of 10 compounds had been performed against S-180. Among them the compounds T1-2 and T1-6 had been found to possess exce-llant antitumor activity, which tumor-inhibition activities were differentely27% and 24%, which were higher than that of antineoplaston A10 (23%), but less than that of adriamycins (23%) .

关 键 词：抗瘤酮A10 抗瘤酮衍生物 抗癌药 

分 类 号：TQ463.24[化学工程—制药化工]