大鼠脑血栓形成时心功能不全发生机制的探讨  

Studies on the Mechanism of Cardiac Abnormality in Cerebral Thrombosis Rats

作　　者：李树清[1] 韩红[1] 赵文洁[1] 杨琼英[1] 何洁[1] 

机构地区：[1]昆明医学院病理生理教研室

出　　处：《基础医学与临床》1994年第3期25-29,共5页Basic and Clinical Medicine

基　　金：云南省科委应用基础研究基金

摘　　要：以脑水含量、局部脑血流（ｒＣＢＦ）、全血血小板聚集、心输出量（ＣＯ）、每搏出量（ＳＶ）、心率（ＨＲ）、平均血压（ＭＡＰ）、外周总阻力（ＴＰＲ）及心、肝、脾。肾和肾上腺局部血流量（ｒＢＦ）为指标，探讨光化学法诱导的实验注血栓形成性局部脑缺血时全血血小板功能改变对心功能的影响及其机理。结果表明，光化学反应后４小时，全血血小板聚集明显增强（ｐ＜０．０１），ＣＯ、ＳＶ降低（ｐ＜０．０５）；２４小时ｒＣＢＦ、ＣＯ、ＳＶ及心肌ｒＢＦ均明显减少，ＴＰＲ及脑水含量明显增加（ｐ＜０．０１）；２４小时后，心血管指标的改变随血小板聚集的减弱而逐渐恢复至对照水平。提示血小板功能改变在脑血栓形成所致心功能异常中起重要作用。n order to study the mechanism of cardiac insufficiency in thrombotic cereb- ral ischemia,a new photochemically method was employed to cause regional cereb- ral thrombosis in the stat. The changes of brain water content, regional cerebralblood flow(rCBF),whole blood platelet aggregation, cardiac output(CO), strokevolume(SV),heart rate(HR),mean blood pressure(MAP),total preipheral resistanc(TPR)and the regional blood flow (rBF)in heart,liver,spleen,kidney and adrenalwere measured and the effects of alteration of platetlet aggregation on cardiacfunotion in cerebral thrombosis have been discussed these results showed that thewhole blood platelet aggregation increaased markedly(p<0.01)and CO,SV decreased(p<0.05)in 4 hours;the rCBF,CO,SV and myocardial blood flow were significantlyreduced and TPR,brain water content increased markedly(p<0.01)in 24 hours;thecardiovasular parameters began to return to the control level with platelet aggre- gation reduced after 24 hours.The results suggest that increased platelet aggregationmay play an important pole in cerebral thrombosis leading to the cardiac abnorma-lities.

关 键 词：脑血栓形成 血小板聚集 心功能 

分 类 号：R743.320.2[医药卫生—神经病学与精神病学]