脑缺血和重灌流不同时程血浆β-内啡肽含量的实验观察  

AN EXPERIMENTAL STUDY OF β-EP CONTENT IN PLASMA ON ACUTE CEREBRAL ISCHEMIA AND REPERFUSION

作　　者：白波 王宏 葛凤 刘文彦 王曙光 

出　　处：《济宁医学院学报》1994年第1期1-3,共3页Journal of Jining Medical University

摘　　要：采用放射免疫分析技木测定了沙土鼠急性脑缺血不同时程和缺血后重灌流不同时间血浆β－内啡肽含量的动态变化。结果表明：脑缺血１５ｍｉｎ、６０ｍｉｎ、１２０ｍｉｎ血浆β－内啡肽含量显着升高。急性脑缺血３０ｍｉｎ后重灌流９０ｍｉｎ，实验组和单纯脑缺血１２０ｍｉｎ组相比，血浆β－内啡肽含量明显降低。提示测定血液或脑脊液中β－内啡肽含量的动态变化规律，有利于脑中风患者的临床诊治和预后判断。急性脑缺血３０ｍｉｎ后重灌流９０ｍｉｎ，有利于沙土鼠神经组织的功能恢复。Dynamic changes of β-EP content in Plasma was measured by RIA in gerbi is following acute cerebral ischemia and reperfusion. The resulits sho wed that β-EP content of gerbilsin plasma increased significantly in cerebrali schemia 30min. 60 min. and 120 min. groups. while in the cerebral ischernia 30 min.followiug reperfusion 30 min. and 90 min. groups remarkably decreased compared with that of ischemia 60min. and 120min. groups. It is suggested that to measure the content of β-Ep in plasma and CF is benificial to diagnos and treat the stroke. Recovering the normal function of nervous tissue is advantage by reperfusion followed cerebral ischemia;30 min. in Mongolian gerbils.

关 键 词：脑缺血 重灌流 内啡肽 放射免疫 

分 类 号：R743.302[医药卫生—神经病学与精神病学]