致倦库蚊（Culex　pipiens　quinquefasciatus）引诱产卵信息素的合成及其生物活性  

SYNTHESIS AND SPECIES SPECIFIC ATTRACTANCY OF AN OVIPOSITION ATTRACTANT PHEROMONE OF CULEX PIPIENS QUINQUEFASCIATUS

作　　者：张金桐 刘珣[1,2] 孔杰[1,2] 张钟宁[1,2] 白云秀 

机构地区：[1]军事医学科学微生物流行病研究所 [2]中国科学院动物研究所

出　　处：《寄生虫与医学昆虫学报》1994年第1期45-50,共6页Acta Parasitologica et Medica Entomologica Sinica

基　　金：国家自然科学基金

摘　　要：致倦库蚊（Ｃｕｌｅｘｐｉｐｉｅｎｓｑｕｉｎｑｕｅｆａｓｃｉａｔｕｓ）产生的引诱产卵的信息素被鉴定为赤式－６－乙酰氧基－５－十六碳内酯。用环戊酮和十一碳醛经醇醛缩合产生２－（１－羟基十一烷基－１－）环戊酮，再通过拜尔－维利格反应和乙酰化作用合成了这种内酯的赤式和苏式异构体的混合物。合成产物由等比例的四种异构体组成，包括具有活性的赤式－（５Ｒ，６Ｓ）和它的对映异构体，以及另外两个苏式异构体。用合成的信息素对四种（亚种）蚊虫做了引诱产卵的生物测定，发现该产物对同种不同亚种的淡色库蚊（Ｃｘ．ｐｉｐｉｅｎｓｐａｌｌｅｎｓ）和致倦库蚊均有引诱雌蚊产卵的活性，且对前者的引诱力更强，并能保持至少１０天以上；而对同属不同种的三带喙库蚊（Ｃｘ．ｔｒｉｔａｅｎｉｏｒｈｙｎｃｈｕｓ）和另一个属的埃及伊蚊（Ａｅｄｅｓａｅｇｙｐｔｉ）则无活性，表明该信息素具有种的（而非属的）特异性。The oviposition attractant pheromone of Culex pifoens quinque fasciatus was identified as erythro-6-acetoxy-5-hexadecanolide. A mixture of erythro-and threo-isomers of the lactone was synthesized by the aldol condensation from cyclopentanone and undecanol,producing 2-(1-hydroxyl undecyl-1-)cyclopentanone,then by the Baeyer-Villiger reaction and acetyoation. The synthetic product was consisted of equal protportions of four isomers including the active erythro-(5R,6S) and its enantiomer, and another two threo-enantiomers.Oviposition attractancy tests were made with the synthetic pheromone to four species/subspecies of mosquitoes.The synthetic pheromone showed an attractant effect to both Cx.p. pellens and Cx. p. quinque fasciatus,with a stronger effect to the former and keeping it for at least 10 days,and no effect to Cx. tritaeniorhynchus and Aedes aegypti,inferring that the pheromone is of species,but not genus,specificity.

关 键 词：致倦库蚊 引诱产卵 信息素 合成 

分 类 号：R384.1[医药卫生—医学寄生虫学]