陕西地区食管癌的遗传流行病学研究  

STUDY ON GENETIC FPIDEMIOLOGY OF ESOPHAGEAL CANCER(EC)IN SHANXI REGION

作　　者：韩成龙[1] 李良寿[1] 蒋豫图[1] 张习坦[1] 

机构地区：[1]第四军医大学流行病学教研室,军事医学科学院微生物流行病研究所

出　　处：《解放军预防医学杂志》1994年第1期25-28,共4页Journal of Preventive Medicine of Chinese People's Liberation Army

摘　　要：本文采用流行病学病例对照研究方法调查分析了３０５例食管癌病例和６００例医院对照者亲属中食管癌的发病情况。结果表明，患者Ⅰ级亲属中食管癌的发病率为３．５９％（５８／１６１４），Ⅱ级亲属为０．９７％（１４／１４４７）；而对照亲属仅为０．５９％（５４／９２０７）。用Ｌｉ－Ｍａｎｔｅｌ－Ｇａｒｔ法估计得食管癌的分离比为０．０２７０～０．０５１２，不符合单基因遗传规律。用Ｆａｌｃｏｎｅｒ法估计得患者Ⅰ级亲属中食管癌的遗传度为５８．７１±４．２９％，Ⅱ级亲属中为１５．５７±１４．１６％，Ⅰ、Ⅱ级亲属加权遗传度为４８．６８±１８．１５％。结果说明陕西地区食管癌的发病中遗传因素虽起一定作用，但不是主要因素。ith epidemiological method, we investigated the EC incidence amongfamily members of 305 EC cases and 600 hospital control cases. It wassliown that the EC incidence among the first relatives, second relatives ofEC and control relatives was 3.59%,0.97%,and 0.59%respectively. WithLi-mantel-Gart method, segregation ratio of EC in siblings was about 0.0270～0.0512.With Falconer’s multifactorial threshold model, heritability of ECin first and second reletives was 58.71 ±4.29%, 15.57±14.16%respectively.It suggests that genetic factor does not play a major role in the eitiologyof EC.

关 键 词：食管肿瘤 癌 流行病学 多基因遗传 

分 类 号：R735.1[医药卫生—肿瘤]