丙氨酸锗抗肿瘤活性及免疫效应  

ANTITUMOR ACTIVITY AND IMMUNOLOGICAL EFFECT OF ALANINE-GERMANIUM

作　　者：葛学美[1] 赵法[1] 郭俊生[1] 陈洪章[1] 朱平民 吉玉申 

机构地区：[1]第二军医大学军队卫生教研室

出　　处：《解放军预防医学杂志》1994年第5期341-344,共4页Journal of Preventive Medicine of Chinese People's Liberation Army

摘　　要：为探讨丙氨酸锗的抗肿瘤活性及免疫效应，本文进行了两个瘤株的抗肿瘤实验和免疫实验。结果表明：丙氨酸锗能明显延长移植Ｈ＿（２２）肝癌腹水型小鼠的生存时间，抑制Ｓ＿（１８０）肉瘤生长，提高Ｔ淋巴细胞￣３Ｈ－ＴｄＲ掺入指数，增强单核吞噬细胞吞噬功能。提示丙氨酸锗具有抗肿瘤活性，其抗肿瘤活性可能是通过提高机体免疫机能实现的。n order to study the antitumor activity and immunological effect ofalanine-germanium,the tests had been made,The results showed thatalanine-germanium could obviously extend the survival time of mice with H_(22)ascites tumor and retard the growth of sarcoma 180.The stimulating index(￣3H-TdR) of T-cell stimulated by ConA of alanine-germanium group wasmuch higher than that of the control,It also exhibited obvious enhancementof corrected phagocytici ndex of the mononuclear phagocytes in groups ofdifferent doses.These results indicated that alanine-germanium had anti-tumor activity and this effect was realized probably through the route ofenhancement of immunopotency.

关 键 词：丙氨酸锗 肿瘤 效应 

分 类 号：R730.53[医药卫生—肿瘤]