原发性肝癌患者介入治疗期间的NK活性变化  

The Effect of NK Cell Function in Peripheral Blood of Patients with Advanced Primary Liver Cancer During Interventional Treatment

作　　者：董永华[1] 袁弥满[1] 林贵[1] 

机构地区：[1]上海医科大学附属中山医院,200032

出　　处：《介入放射学杂志》1994年第4期197-200,共4页Journal of Interventional Radiology

摘　　要：随机选择60例在本院接受介入治疗的原发性肝癌患者分为三组:Ⅰ组(20例)采用本院常规的介入治疗方案,Ⅱ组(20例)采用常规介入治疗的同时,分别在术后2小时和48小时,静脉滴注硫代硫酸钠4g,共计8g。Ⅲ组(20例)在Ⅰ组的相同条件下于术后1周开始肌注干扰素100万单位,每周二次二个月以上。结果表明:原发性肝癌患者的 NK 活性明显低于正常健康人群,经介入治疗后,NK 活性显示为逐渐下降;在术后加用硫代硫酸钠能够有效的保持 NK 活性,较长期地低剂量干扰索可以在一定程度上提高患者的 NK 活性。NK cell function was tested in 60 patients randomly selected with ad- vanced primary liver cancer(PLC)during interventional treatment.The patients were di- vided into three groups and treated with different regimens.In group 1(n=20),routinally using HAI(5-Fu 1000mg,CDDP 30mg)and HAE(Lipiodel 10～20ml,EAMC 50mg)in group 2,the treatment project is same as in group 1,but after the treatment,total 8g Natrii thiosulfas was administrated intravenously within 48 hours;in group 3,one week after treatment as in group 1,the patients received a-2b IFN injected subcutaneously at a dose of 10×10~6 IU,B.i.w,for more than 2 months.The results showed that:1.NK function in the patients with advanced PLC was 17.45±4.5% ,significantly lower than that in the nor- mal ones(21.39±3.58%);2.After the interventional treatment,the NK function of the patients were obviously decreased in group 1(13.58±3.14%),and in group 2(15.45±2. 69%),but increased in group 3(19.20±3.27%).The results suggested that conventional interventional treatment will affect NK cell function of patients with advanced PLC in some degree,and the effect can be reduced by injecting Natrii Thiosulfas i.v.,and administering IFN.

关 键 词：NK细胞 肝肿瘤 介入疗法 

分 类 号：R730.55[医药卫生—肿瘤] R818.023[医药卫生—临床医学]