鼻咽癌与前列环素及血栓素关系初探  

A preliminary approach to concentrations of plasma PGI_2 and TXA_2 in nasopharyngeal neoplasms

作　　者：诸汉启 谭慎微 刘永强[1] 

机构地区：[1]同济医科大学附属同济医院耳鼻咽喉科,同济医科大学计划生育研究所生殖医学中心

出　　处：《临床耳鼻咽喉科杂志》1994年第2期67-69,共3页Journal of Clinical Otorhinolaryngology

摘　　要：用放射免疫法分别测定了３４例鼻咽癌、１６例良性瘤、１２例炎症和１６例正常人外周血浆中前列环素（ＰＧＩ２）和血栓素Ａ２（ＴＸＡ２）的稳定代谢产物６－酮－前列腺素Ｆ１ａ。（６－ｋｅｔｏ－ＰＧＦ１ａ）和血栓素Ｂ２（ＴＸＢ２）的含量。结果显示鼻咽癌患者血浆ＴＸＢ２含量显著升高（Ｐ＜０．０１），ＰＧＩ２含量也有所增加；ＴＸＢ２／６－ｋｅｔｏ－ＰＧＦ１ａ比值显著增加（Ｐ＜０．０１）。鼻咽癌晚期患者血浆ＴＸＢ２含量显著高于早期患者（Ｐ＜０．０５）。提示ＰＧＩ２和ＴＸＡ２水平，尤其是ＴＸＡ２可作为鼻咽癌发展及转移的参考指标。A radioligand binding assay was used to evaluate the level of plasma TXB2 and 6-keto-PGF1a in 34 patients with carcinoma of nasopharynx. The results demonstrated that the level of 6-keto-PGF1a and TXB2 in plasma increased in patient with cancer cases as compared with normal controls, the level of TXB2;increased significantly(P< 0. 01 ). Also the level of TXB2 was significantly increased in plasma of advanced cases than those in primary cases(P<0. 01), These results suggested that the level of TXA2/PGI2,especially TXA2, should be implicated as possible facilitative agents in growth and dissemination of nasopharyngeal neoplasms.

关 键 词：前列环素 血栓素 鼻咽肿瘤 癌 

分 类 号：R739.630.2[医药卫生—肿瘤]