雷诺现象的转归研究  

Study on the evolution of Raynaud's phenomenon

作　　者：华国勋 王书桂 赵国忠[1] 黄平平 李尚珠[1] 

机构地区：[1]中国医学科学院血液病医院,中国医学科学院血液学研究所

出　　处：《临床皮肤科杂志》1994年第5期238-240,共3页Journal of Clinical Dermatology

摘　　要：将可供长期随访的雷诺现象患者８０例分为两组：原发性雷诺现象组及疑继发性雷诺现象组。经平均６．０３年随访后，前组５２例中仅２例发展为结缔组织病，后组２８例中有１３例发展为结缔组织病，两组差别显著（Ｘ２＝１１．３７，Ｐ＜０．００５）。分析结果示，雷诺现象伴甲皱循环异常，抗核抗体阳性及γ－球蛋白升高与发展为结缔组织病有密切关系。Patients with Raynaud's phenomenon (RP) were followed up for an average duration of 6.03 years. They were classified into 2 groups upon the initial evaluation:the primary RP group and the suspect secondary RP group. On final evaluation,2 out of the 52 patients in the primary RP group developed a definite connective tissue disease,whereas 13 out of the 28 patients in the secondary RP group had their definite diagnosis of CTD.The three parameters strongly associated with subsequent development of an overt connective tissue disease were: abnormal capillary pattern in nailfold, presence of antinuclear antibodies and raised serum r-globulin level.

关 键 词：雷诺氏病 转归 胶原病 

分 类 号：R747.302[医药卫生—神经病学与精神病学]