出血性卒中患者脑脊液微量元素和抗氧化酶含量的研究  

Changes of the CSF trace elements and antioxidase in patients with hemorrhagic stroke.

作　　者：方思羽[1] 王桂珍[1] 曹学兵[1] 王军[1] 吕玲[1] 

机构地区：[1]同济医科大学同济医院神经科,同济医科大学实验医学研究中心

出　　处：《临床神经病学杂志》1994年第2期85-87,共3页Journal of Clinical Neurology

摘　　要：本文测定３６例脑出血、３１例ＳＡＨ患者的脑脊液微量元素和抗氧化酶含量的变化，结果发现：脑出血和ＳＡＨ的脑脊液锌、硒、铬、铁、镁含量，ＧＳＨ－Ｐｘ活性和Ｇ／Ｍ比值明显低于对照组（Ｐ＜０．０５或Ｐ＜０．０１），铜、ＭＤＡ含量及ＳＯＤ活性明显高于对照组（Ｐ＜０．０５或Ｐ＜０．０１）。提示：微量元素和抗氧化酶与出血性卒中有密切关系。AbstractThe concentrations of the CSF trace elemen ts and an tioxidase activities were determined in 67 patients with hemorrhagic stroke.2 7 patients with surgical disease were also stud ied as con-trols.The results showedthat in CSF,the concen trations of zinc,selenium,chromium,iron and magnesium,glutathione peroxidase(G)activity and the G/M ratio were significantly desreased(P<0. 05 or P<0.01),while the concentrations of copper and malonyldialdehyde(M)and superox-ide dismutase activity in CSF were signifieantly increased(P< 0. 05 or P<0.01)when compared with controls.It is suggested that changes of the CSF trace elements and antioxidase activities men-tioned above are closely correlated with hemorrhagic stroke.

关 键 词：中风 脑出血 微量元素 抗氧化酶 

分 类 号：R743.340.2[医药卫生—神经病学与精神病学]