几种小儿神经系疾病白细胞介素Ⅱ受体和自然杀伤细胞的观察  

IL-2R and CD16 in nervous diseases of children

作　　者：梁英仪[1] 赵早鱼[1] 陶拉锑 李世光[1] 岳月娥[1] 赵俊萍[1] 

机构地区：[1]山西省儿童医院,山西医学院儿科系

出　　处：《临床神经病学杂志》1994年第5期277-279,共3页Journal of Clinical Neurology

摘　　要：采用间接免疫荧光法对小儿病脑（７４例）、化脑（６６例）及癫痫（５３例）患儿外周血白细胞介素Ⅱ受体（ＩＬ－２Ｒ）及自然杀伤细胞（ＣＤ１６）进行了检测，结果显示：①病例组ＩＬ－２Ｒ和ＣＤ１６均明显高于对照组（Ｐ＜０．０１）；②ＩＬ－２Ｒ在病脑、化脑急性期升高尤为明显，恢复期有所下降，与病情呈正相关（Ｐ＜０．０１和Ｐ＜０．０５）；③ＣＤ１６的改变与ＩＬ－２Ｒ的改变相平行，但在病脑恢复期无明显下降。从而提示病脑、比脑及癫痫患儿均存在免疫功能系乱，ＩＬ－２Ｒ可能是上述疾病时参与免疫应答的重要细胞因子的表达，ＣＤ１ｅ的改变与ＩＬ－２Ｒ的升高有关，对临床病情估计和预后判断有一定意义。AbstractWe assayed peripheral blood IL-2R and CDi 6 cell in 74 patients with viral encephalitis,66 patients with bacterial meningitis and 53 patients with epilepsy in children,using IFAT methed.The results indicated that:(1)IL-2R and CD16 rates were significantfy elevated in all of the 3 groups when compared with control guoup(P< 0. 01).(2)In acute phase of viral encephalitis and bacterial meningitis IL-2R were highest, but in recovery phase it dropped and showed positive relation with conditions of the disease(P<0. 01)(3)The change of CD16 was parallel to IL-2R. But in recovery phase of viral encephalitis there was no obvious decrease. The results suggest that in the existing immunological disturbances of the above diseases, IL-2R may be an important expression of cell factor,which attends immune reaction. The change of CD16 is related With elevated IL-2R. They may be significant for clinical evaluation of the degree and prognosis of the above-mentioned diseases.

关 键 词：儿童 白细胞介素Ⅱ 杀伤细胞 天然 神经系统疾病 

分 类 号：R748.03[医药卫生—神经病学与精神病学]