乳腺单纯癌细胞形态定量及临床病理特征与预后的关系  

Relation of Prognosis to Clinical Pathological Features,Cell Morphometry and Steroid Hormone Receptors of Breast Carcinoma Simplex

作　　者：吴强[1] 王保太[1] 饶慧蓉[1] 杨枫[1] 刘琛[2] 

机构地区：[1]安徽医科大学病理学教研室,合肥230032 [2]安徽中医学院附属医院

出　　处：《临床与实验病理学杂志》1994年第4期290-292,共3页Chinese Journal of Clinical and Experimental Pathology

基　　金：安徽省教委及北京中关村地区联合分析测试中心资助

摘　　要：分析33例乳腺单纯癌细胞形态定量、临床病理特征及性激素受体(SR)表达与术后5年生存率的关系。结果显示:(1)癌细胞核大(包括平均核直径、周长、面积)、异型性明显、形状因子小、核分裂象多见者预后差;(2)组织学Ⅰ-Ⅱ级、SR表达水平高、无淋巴结转移者及高龄患者预后较好;(3)少数单纯癌虽然细胞核小,但若细胞分化较差、缺乏SR表达且伴有淋巴转移者仍预后不良。表明综合考虑单纯癌细胞和组织病理学特征、SR状态及临床特点,才能更好地估计预后。The relation of patient 5-year survival rate to the clinical pothologlcal features, cell morphometry and steroid hormone receptors (SR) expression of 33 cases breast carcinoma simplex was studied. The results showed that (1) there were some cy-tological parameters implying poor prognosis , i. e. Large nuclear including mean nuclear diameter, perimeter and area, obvious nuclear pleomorphism, little nuclear shape factor, and more mitotic figures, (2) there was a high survival rate in patients over the age of 40 years and with tumors of histolog-ic grade Ⅰ - Ⅱ , SR positive and having no lymphnode involvement, (3) in a few cases of patients with carcinoma simplex of which the nuclei were small, they could not survive longer after operation, when the cancer cells were low differentiated, lack of the expression of SR and spread to axillary lym-phnodes.

关 键 词：乳腺癌 病理 类固醇激素受体 预后 

分 类 号：R737.902[医药卫生—肿瘤]