人胚胸腺移植对肿瘤化疗患者的保护作用  

THE PROTECTIVE EFFECT OF HUMAN FETAL THYMUS TRANSPLANTATION ON TUMOR PATIENTS DURING CHEMOTHERAPY

作　　者：韩玉美[1] 张玲[1] 刘树芬[1] 肖东杰[1] 张劭夫[1] 董洪涛[1] 崔正言[1] 

机构地区：[1]山东省医学科学院基础医学研究所免疫室,中国人民解放军济南军区总医院

出　　处：《山东医科大学学报》1994年第3期196-198,共3页Acta Academiae Medicinae Shandong

摘　　要：检测了３６例肿瘤患者Ｔ细胞亚群的变化，并在患者接受化疗期间对１４例进行了人胚胸腺移植，检测了移植前后患者白细胞的总数及细胞、体液免疫功能。结果显示肿瘤患者细胞免疫功能紊乱，移植人胚胸腺前后白细胞总数无明显变化，而ＯＫＴ＿３和ＯＫＴ＿４较移植前有明显提高（Ｐ＜０．０５）。提示人胚胸腺移植可调整肿瘤患者机体免疫功能和促进骨髓造血功能，保证化疗的进行。in this paper, we observed the T cell subsets of 36 tumor patients, meanwhile, 14 of these patients were transplanted with human fetal thymus during chemotherapy.We detected the number of WBC,function of cellular and humoral immunity before and after transplantation. The results showed that immune function disordered in the tumor patients, the total number of WBC had not obvious difference before and after transplantation, however, OKT3 and OKT4 increased significantly after transplantation. These result suggested that the transplantation of human fetal thymus could regulate immune function, and improve hemopoietic function of bone marrow of tumor patients, so it could pledge progress successfully of chemotherapy of tumor patients.

关 键 词：移植 胚胎 胸腺 肿瘤 药物疗法 

分 类 号：R730.53[医药卫生—肿瘤]