人胎肝抑瘤物体外净化自体骨髓治疗急性白血病13例报告  

AUTOLOGOUS BONE MARROW TRANSPLANTATION AFTER PURGING BY LOW MOLECULAR WEIGHT NATURAL TUMOR SUPPRESSOR IN THE TREATMENT OF 13 CASES OF ACUTE LEUKEMIA

作　　者：朱军[1] 姚善谦[1] 刘海川[1] 王连元[1] 楼方定[1] 阎影[1] 周绮[1] 刘景汉[1] 王小沛[1] 裴雪涛[1] 吴祖泽[1] 劳妙芬[1] 徐黎[1] 

机构地区：[1]解放军总医院,军事医学科学院放射医学研究所

出　　处：《山西白血病》1994年第1期25-27,共3页

摘　　要：用人类胎肝低分子天然抑瘤物（ＬＭＷ－ＮＴＳ）对１３例缓解期（ＣＲ）急性白血病休外净化后自体骨髓移植（ＡＢＭＴ），其中ＡＬＬ４例（ＣＲ１３例，ＣＲ２１例），ＡＮＬＬ９例（ＣＲ１７例，ＣＲ２２例）。１２例获造血重建，１例因霉菌败血症早期死亡。移植后持续缓解８例，缓解时间＞１２个月７例，＞６个月１例。４例移植后３月～６月复发。木文对该净化方法及ＡＢＭＴ近期疗效进行讨论。3 acute leukemia patients(4 ALL patients and 9 ANLL patients were treated by autologous bonemarrow transplantation(ABMT). Marrow grafts were purged by a low molecular weight naturaltumor suppressor(LMW-NTS ) before.In the 12 patients transplanted, 7 patients have achieved complete remission more than12monthes , another 1 patient got complete remission more than 6 months. 1 patient died of marrow graftfailure with fungi septicaemia on the day 37 after ABMT. 4 patients relapsed 3～6 months afterABMT. The results indicated that the hemotopoietic reconstitute can be achived in such patients andthe purging effect of LMW-NTS needed to be observed furthe

关 键 词：自体 骨髓移植 白血病 体外净化 

分 类 号：R733.710.5[医药卫生—肿瘤]