白血病患者血浆和外周血白细胞内维生素的研究  

A STUDY ON VITAMIN LEVELS IN PLASMA AND PERIPHERAL LEUKOCYTES IN PATIENTS WITH LEUKEMIA

作　　者：韩洁英[1] 李蓉蓉[1] 缪金明[1] 宣正华[1] 刘辉[1] 邵念贤[1] 郑迪辉 蒋贝子[1] 欧阳仁荣[1] 

机构地区：[1]上海第二医科大学附属仁济医院血液科,上海血液学研究所白血病研究室,上海市消化疾病研究所

出　　处：《上海医学》1994年第3期132-136,共5页Shanghai Medical Journal

摘　　要：本文检测４６例正常人和４４例不同类型白血病血浆和外周血白细胞内维生素Ｅ、Ａ、Ｃ、Ｂ１２、β－胡萝卜素和叶酸浓度。结果表明，白血病血浆内β－胡萝卜素降低（Ｐ＜０．００１），Ｂ１２显著增高（Ｐ＜０．００１），外周血白细胞内维生素ＥＢ１２和β－胡萝卜素均低于正常对照组（Ｐ＜０．００１和＜０．０５）。在各类型白血病比较中，ＡＬＬ血浆维生素Ａ和β－胡萝卜素高于正常对照组和髓系白血病（Ｐ＜０．００１），ＣＭＬ者维生素Ｂ１２高于ＡＬＬ和ＡＮＬＬ（Ｐ＜０．００１）。分析认为选择性维生素代谢异常与不同类型白血病发生有一定的关系。he levels of vitamin E,A,C,B12 ,β-carotene and folic acid in plasma and peri-pheral leukocytes were measured in 4 5 healthy volunteers(controls) and 4 4 patients withvarious types of leukemia. The mean concentration of β- carotene was significantly redu- ced(P<0.001),and the vitamin B12 level was markedly increased(P<0.001)in theplasma of patients with leukemia as compared with the controls. The contents of vita- min E,B12,and β- carotene in the peripheral leukocytes of patients were significantlylower(P<0.001,and P<0.05, respectively)than that in the controls. Vitamin A andβ-carotene levels in plasma of patients with acute lymphocytic leukemia(ALL)weresignificantly higher than that of controls and patients with myloid leukemia(P<0. 001and<0.01,respectively).Vitamin B12 in plasma of patients with chronic myelocytie- leukemia was markedly higher as compared with ALL and acute non-lymphocytic leuke-mia(P<0.001),It is suggested that the abnormality of vitamin metabolism in plasmaand leukocytes mentiond above were associated with the development of various typesof leukemia.

关 键 词：白血病 维生素A 维生素E 

分 类 号：R733.7[医药卫生—肿瘤]