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作 者:陈起亮 李金华[1] 刘惠慈[1] 顾风[1] 印其章[1]
出 处:《生理学报》1994年第2期193-197,共5页Acta Physiologica Sinica
摘 要:在大鼠新生期注射谷氨酸单钠(MSG),观察动物成年后应激时的镇痛效应和血浆皮质酮反应。以新生期注射10%NaCl作为等渗对照。MSG组大鼠下丘脑弓状核(ARC)的β-内啡肽(βEND)免疫反应细胞减少60.7%,痛阈和血浆皮质酮的基础值未受影响。在不可躲避的持续电刺激四肢脚底30min后,MSG组动物应激镇痛效应明显降低,但应激仍可使血浆皮质酮水平明显升高(P<0.01)。实验结果提示,ARC的β-END能神经元参与应激镇痛,而对垂体-肾上腺皮质系统应激的血浆皮质酮反应影响不大。In the present investigation,it was found that the number ofβ-endorphin(βEND)-immunoreactive neurons of hypothalamic arcuate nucleus(ARC)in MSGtreated rats decreased by 60.7 %.No significant differences in the baseline pain thresholdand the baseline corticosterone(CS)level were observed between the MSG-treatedgroup and the control group.After electrical foot shock for 30 min,the analgesia effect was decreased significantly(P<0.001)in MSG-treated rats,while the CS levelsof both MSG-treated rats and control rats were increased remarked(P<0.01).The results suggest that the β-END neurons of ARC were involved in analgesia,but not in CSreaction during stress.
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