大鼠新生期注射谷氨酸单钠成年后应激时的镇痛效应和血浆皮质酮反应  被引量:4

THE ANALGESIA EFFECT AND PLASMA CORTICOSTERONE REACTION DURING STRESS IN ADULT RATS TREATED NEONATLLY WITH MONOSODIUM GLUTAMATE

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作  者:陈起亮 李金华[1] 刘惠慈[1] 顾风[1] 印其章[1] 

机构地区:[1]苏州医学院生理学教研室,神经生物学研究室

出  处:《生理学报》1994年第2期193-197,共5页Acta Physiologica Sinica

摘  要:在大鼠新生期注射谷氨酸单钠(MSG),观察动物成年后应激时的镇痛效应和血浆皮质酮反应。以新生期注射10%NaCl作为等渗对照。MSG组大鼠下丘脑弓状核(ARC)的β-内啡肽(βEND)免疫反应细胞减少60.7%,痛阈和血浆皮质酮的基础值未受影响。在不可躲避的持续电刺激四肢脚底30min后,MSG组动物应激镇痛效应明显降低,但应激仍可使血浆皮质酮水平明显升高(P<0.01)。实验结果提示,ARC的β-END能神经元参与应激镇痛,而对垂体-肾上腺皮质系统应激的血浆皮质酮反应影响不大。In the present investigation,it was found that the number ofβ-endorphin(βEND)-immunoreactive neurons of hypothalamic arcuate nucleus(ARC)in MSGtreated rats decreased by 60.7 %.No significant differences in the baseline pain thresholdand the baseline corticosterone(CS)level were observed between the MSG-treatedgroup and the control group.After electrical foot shock for 30 min,the analgesia effect was decreased significantly(P<0.001)in MSG-treated rats,while the CS levelsof both MSG-treated rats and control rats were increased remarked(P<0.01).The results suggest that the β-END neurons of ARC were involved in analgesia,but not in CSreaction during stress.

关 键 词:谷氨酸单钠 应激镇痛 血浆 皮质酮 

分 类 号:R971.1[医药卫生—药品]

 

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