宫颈粘膜癌变过程中DNA含量、Ag—NOR及核形态变化的定量分析  

Quantitative Analysis of DNA Content A-gNOR and Nucleus/cytoplasm Ratio Within Cervical Mucosal Canceration

作　　者：刘坤平[1] 郑杰[1] 胡文浩[1] 李宏安 潘晓琳[1] 郭长军[1] 张素清[1] 高志斌[1] 吴玉新[1] 

机构地区：[1]石河子医学院病理教研室

出　　处：《石河子医学院学报》1994年第1期22-25,共4页

基　　金：新疆维吾尔自治区卫生厅青年科学基金资助课题

摘　　要：对54例宫颈鳞状上皮不典型坛生、原位癌、鳞癌Ⅰ级、Ⅱ级、Ⅲ级进行核仁组成区相关嗜糖蛋白（Ag-NOR）计数,同时利用图像分析技术对其中的25例进行DNA含量的原位定量及核浆比测定,结果8C及8C以上细胞群的出现是判断肿瘤恶性程度的重要指标。Ag-NOR计数及核浆比与细胞DNA含量变化呈正相关,随病理分级逐级增高,并在判断肿瘤恶性程度上有一定意义。The quantitative counting research of silver-binding nucleolus organizer region (Ag-NOR) was made in 54 cases of patients with cervical squamous epithelium atypical hyperpla-sia carcinoma in situ, squamous cell carcinoma grade Ⅰ、Ⅱ、Ⅲand DNA content in situ, nucleus/cytoplasm ratio were measured with computer-assisted image analysis technipue in 25 cases from 54 cases. The results were that the DNA contect increased coincidently during the same process with pathologic histologic grading. The appearance of 8c and over 8c cell group was the main factor of DNA contect changing. The appearance rate was the important criterion of neoplasm malignant degree judgment. Ag -NOR couting and nucleus /cytoplasm ratio was positively correlated with DNA content and increased coincidently during the same process with pathologic histologic grading, too. The result was significant in neoplasm malignant degree judgement.

关 键 词：宫颈癌 DNA 核浆比 图像分析 

分 类 号：R737.330.2[医药卫生—肿瘤]