用感染包虫病的小鼠筛选药物  

SCREENING DRUGS AGAINST HYDATID CYSTS HARBOURED IN MICE

作　　者：尤纪青[1] 焦佩英[1] 郭惠芳[1] 高芳华[1] 肖树华[1] 柴君杰 张文林 焦伟 

机构地区：[1]中国预防医学科学院寄生虫病研究所 [2]新疆自治区地方病防治研究所

出　　处：《地方病通报》1989年第2期44-51,共8页Endemic Diseases Bulletin

摘　　要：应用感染继发性包虫病的小鼠筛选了89个不同类型的化合物,其中以甲苯达唑的抗包虫效果较好,在所筛选的噻二唑类化合物,吡喹酮类化合物及苯硫脲嗪亦有一定的抗包虫效果,值得进一步研究。Mice,each inoculated with 2000 ptotoscoleces Echinococcus granulosus for 5-6 months were used as an animal model for screening drugs. Eighty-nine compounds with different chemical formulae have been tested, and among them only mebendazole showed a better therapeutic effect on hydatid cysts. Besides, thiodiazole compounds, praziquantel analogues and phenthiourezine also exhibited some effect against hydatid cysts in mice. Further studies on thesec compounds would be helpful for developing new anti-hydatid disease drugs.

关 键 词：包虫病 药物筛选 噻类化合物 

分 类 号：R532.32[医药卫生—内科学]