静脉滴注尼莫地平对颅内动脉瘤破裂后脑血管痉挛的防治  

Trial of Intravenous Nimodipine in Patients with Intracranial Aneurysm after Clipping Operation to Prevent Cerebral Vasospasm

作　　者：杨树源[1] 杨玉山[1] 李庆彬[2] 陶宗民 张俊廷[3] 王硕[3] 李京生[3] 

机构地区：[1]天津医学院附属医院,300052 [2]天津市脑系科医院 [3]北京天坛医院

出　　处：《天津医药》1994年第6期330-332,共3页Tianjin Medical Journal

摘　　要：多中心、前瞻性对照研究62例颅内动脉瘤破裂后引起蛛网膜下腔出血,行动脉瘤夹闭手术后14天的结果。31例于动脉瘤夹闭术后给予2mg/h国产尼莫地平连续输入7～14天预防术后脑血管痉挛。31例作为对照。预防组术后脑功能改善率为80.64％,无死亡者,对照组为29％,术后6.43％死亡。5例出现脑血管痉挛者给予尼莫地平治疗,脑功能恢复率为68.8％,而5例对照组仅为35％。本研究证实国产静脉注射用尼莫地平确有防治脑血管痉挛的作用,值得在临床上推广使用。A multiconter placebo-control prospective study on nimodipine prevention was carried out in three neurosurgery departments. Sixty-two patients of intracranial aneurysms after clipping aneurysms operation were enrolled in the trial. In 31 cases nimodipine was continuously infused by 2mg/h for 7-14 days to prevent cerebral vasospasm. Other 31 patients were in control group. In nimodipine prophylactic group, 80.64% of cases recovered well, no death in this group. In control group, 29% of cases recovered well, the mortality was 6.45%. In 5 patients who had vasospasm, after 14 days treatment 68.8% of cerebral function was recovered, and 35% in 5 patients of control group. In conclusion, we believed that nimodipine was able to prevent and treat cerebral vaso spasm after operation.

关 键 词：颅内动脉瘤 脑血管痉挛 尼莫地平 

分 类 号：R739.41[医药卫生—肿瘤]