球囊法甲氨喋呤内化疗与^(32)磷内放疗治疗脑肿瘤  

Balloon MTX Internal Chemotherapy and 32P Internal Radiotherapy of Brain Tumor

作　　者：崔明芹[1] 李宪锋[1] 辛军[1] 王春香[1] 孙德科[1] 

机构地区：[1]山东省临沂市沂水中心医院神经外二科,山东临沂276400

出　　处：《河北医学》2005年第2期125-126,共2页Hebei Medicine

摘　　要：目的:总结用球囊法甲氨喋呤(MTX)与32磷(32P)对脑肿瘤切除后局部内化疗与内放疗的疗效进行评价。方法:通过用MTX与32P对术后不同部位,不同病理类型的肿瘤化疗与放疗进行随访,以评估疗效。结果:本组45例不同部位、不同病理类型肿瘤的病人进行内化疗与放疗治疗后的MRI及CT追踪复查6～12个月,肿瘤复发7例,均为胶质母细胞瘤,胶质瘤Ⅰ、Ⅱ级、转移瘤、生殖细胞瘤均无复发,有效率为60.3%。结论:由于脑肿瘤的病变部位及病理类型不同,其治疗的结果不同。对脑胶质瘤Ⅰ、Ⅱ级、转移瘤、生殖细胞瘤局部化疗、放疗效果好,对胶质母细胞瘤效果差。本人认为此方法简单,效果确定,联合治疗较术后单纯放疗效果好。Objective: To study and evaluate the efficacy of treatment of post-operative brain tumors with balloon MTX local internal chemotherapy and 32P internal radiotherapy.Method: To evaluate the clinical effects by follow-up on MTX chemotherapy and 32P radiotherapy of brain tumors of different part and pathological type. Result: 45 patients with brain tumors of different part and pathological type have been followed up by CT and /or MRI from 6 to 12 months.Seven patients with glioblastoma have tumors relapsing.Glioma(primary or secondary),metastatic tumors and germinoma didn’t recur.The effectiveness was 60.3%.Conclusion: Efficacy is different with the tumors of different part and pathological type.Local chemotherapy and radiotherapy are prominently effective for the treatment of glioma(primary or secondary),metastatic tumors and germinoma.But they are not effective for glioblastoma.I think this method is easy and the result is remarkable.The therapeutic effects against glioma,metastatic tumors and germinoma could be enhanced if the chemotherapy combined with radiotherapy.

关 键 词：球囊法 甲氨喋呤内化疗 ^32磷内放疗 

分 类 号：R739.41[医药卫生—肿瘤]