经门静脉注入碘油化疗药治疗肝癌的实验研究  

Effect of Iodized Oil and Chemotherapeutic Agents Given via Portal Vein on Hepatic Carcinoma:Study with Animal Model

作　　者：刘鹏程[1] 郭俊渊[1] 王承缘[1] 胡国栋[1] 黄志程[1] 刘绍春[2] 

机构地区：[1]同济医科大学附属同济医院放射科,武汉430030 [2]同济医科大学基础医学院病理解剖教研室,武汉430030

出　　处：《同济医科大学学报》1994年第4期312-314,348,共4页Acta Universitatis Medicinae Tongji

摘　　要：20只实验性肝癌大白鼠和20只正常大白鼠经门静脉注入碘油混悬液，在光学显微镜下观察碘油混悬液在肝脏的分布。结果在癌巢内、癌巢内小血管、肝窦及及中央静脉均见有碘油滴。表明门静脉参与肝癌的血供，经门静脉注入碘油化疗药混悬液可致肝癌细胞坏死，提示对肝癌除了经肝动脉化疗和栓塞外，还可辅以经门静脉的化疗和碘油栓塞。Microscopic examination was carried out after injection of iodized oil into pro-tal veins of 20 rats with hepatic carcinoma and 20 normal rats to observe its distribution in the liver.Oil drops were seen in tumor cell lines,small blood vessels inside the cancer nest,the sinusoids,and the central veins.The results showed that protal vein involved in the blood supply of liver cancer and tumor cell necrosis can be achieved after administration of iodized oil and anticancer agent mixture through the protal vein.Transcatheter treatment through the portal vein may be helpful as a supplement to intraarterial treatment of primary liver cancer.

关 键 词：肝肿瘤 门静脉 药物疗法 碘油 

分 类 号：R735.705[医药卫生—肿瘤]