鼻咽癌组织中Survivin蛋白表达及其临床意义  

The clinical significance of the expression of Survivin protein in nasopharyngeal carcinoma

作　　者：姜武忠[1] 伍海军[1] 廖遇平[1] 戴幼艺[1] 刘海峰[1] 张静[1] 卢景琛[1] 朱红[1] 

机构地区：[1]中南大学湘雅医院肿瘤科,湖南长沙410008

出　　处：《中国耳鼻咽喉颅底外科杂志》2005年第1期11-13,共3页Chinese Journal of Otorhinolaryngology-skull Base Surgery

摘　　要：目的　探讨Survivin蛋白表达与鼻咽癌 (NPC)临床及预后的相关性。方法　对 1 992～ 1 994年收治的经病理明确诊断、完成全程根治性放疗、随访 5年以上的 1 1 5例NPC放射治疗前活检标本 (经病理证实均为低分化鳞癌 ) ,应用免疫组织化学技术检测Survivin基因蛋白在NPC组织中的表达情况 ,并分析Survivin的表达与NPC分期、放疗敏感性、生存率、转移和复发之间的关系。结果　NPC组织中Survivin蛋白阳性表达率为 6 8.7%。Survivin的表达活性与鼻咽癌的颈淋巴结转移、放疗敏感性、3年和 5年生存率及复发倾向有密切关系。结论　Survivin高表达对判断病变进展、预测放疗敏感性、颈部淋巴结转移的出现趋势、生存率及转移复发有指导意义。Objective To study the relationship of the protein expression of Survivin gene with the nasopharyngeal carcinoma (NPC) prognosis. Methods The expression of Survivin protein of 115 NPC patients′histological specimen were examined by immunohistochemistory S-P staining before radiotherapy. The 115 patients were treated between 1992-1994, with their pathological diagnosis definite, complishing the whole radiotherapy and being revisited over 5 years. The relationship was studied between the expression of Survivin protein in NPC tissues with clinical stagement of NPC, radiosensitivity of tumor, survival rate of patients, relapse and metastasises of carcinoma. Result The positive rate of Survivin was 68.7%. The clinical stage, metastatic potential of lymph nodes and poor sensitivity to radiotherapy were correlated with expression activity of Survivin protein. The patients with positive Survivin protein expression had worse prognosis than those with negative Survivin expression. Conclusion The high level expression of Survivin protein may be associated with the tumor developing and poor prognosis of NPC.

关 键 词：鼻咽肿瘤倩理学 癌 鳞状细胞/病理学 基因表达 SURVIVIN基因 免疫组化 

分 类 号：R739.63[医药卫生—肿瘤] R730.261[医药卫生—临床医学]