不同甲状腺功能状态对人体胰岛素敏感性的影响  

Influence of different thyriod functional status on human insulin sensitivity

作　　者：郭行端[1] 叶志东[1] 黄玉英[1] 刘君海[1] 

机构地区：[1]广东医学院第二附属医院内分泌科,广东湛江524003

出　　处：《广东医学院学报》2005年第1期30-31,66,共3页Journal of Guangdong Medical College

摘　　要：目的 :研究不同甲状腺功能状态 (甲亢、甲减及正常 )对人体胰岛素敏感性的影响。方法 :选取甲亢患者 36例 ,甲减患者 32例和正常对照 36例并测定其甲状腺激素、血脂、空腹和口服葡萄糖耐量试验 (OGTT) 2 h血糖及胰岛素浓度 ,并计算胰岛素敏感性指数 (ISI)。结果 :校正体重指数 (BMI)、甘油三酯等因素后 ,甲亢、甲减组 ISI显著低于正常对照组 (P<0 .0 5 )。结论 :正常甲状腺功能状态可能是维持人体胰岛素敏感性和正常糖代谢的一个重要因素。Objective: To study the effect of different thyroid function status on insulin sensitivity. Methods: Levels of thyroid hormone, serum lipid, fasting blood glucose and insulin were determined in 36 patients with hyperthyroidism, 32 with hypothyroidism and 36 euthyroid subjects; meanwhile, oral glucose tolerance test (OGTT) was made and insulin sensitivity index (ISI) was calculated. Results: Adjusted with body mass index and triglyceride, ISI was significantly lower in patients with abnormal thyroid function than that in euthyroid subjects (P<0.05). Conclusion: Normal thyroid function could be important in maintaining insulin sensitivity and normal glycometabolism.

关 键 词：甲状腺功能亢进症 甲状腺功能减退症 胰岛素敏感性 

分 类 号：R736[医药卫生—肿瘤]