依碳氯替泼诺的结构分析研究  

Spectra and Structure Data Analysis and Identification of Loteprednol Etabonate

作　　者：叶皓[1] 刘学军[2] 白东鲁[2] 张祥民[3] 

机构地区：[1]上海市药品检验所,上海200233 [2]中国科学院上海生命科学院药物研究所,上海201203 [3]上海复旦大学化学系,上海200433

出　　处：《分析化学》2005年第3期351-354,共4页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金资助项目(No.20075004)

摘　　要：对依碳氯替泼诺的红外光谱(IR)、紫外光谱(UV)、质谱(MS)、氢氢相关谱(1H1HCOSY)、碳谱(DEPT45、DEPT90、DEPT135)、碳氢相关谱(HMQC)数据和解析进行了全面的报道。对所有的1HNMR、13CNMR谱的信号进行了归属,讨论了质谱的主要碎片离子的可能裂解方式和红外所对应的官能团的振动吸收形式、紫外特征吸收峰所对应的不饱和共轭体系电子跃迁能量。The infrared spectrum, ultraviolet spectrum, mass spectrum, H-1 nuclear magnetic resonance spectrum, C-13 nuclear magnetic resonance spectra ( 1313, DEPT- 45, 90, 135), H-1-H-1 correlated spectroscopy (H-1-H-13 COSY), (H-1 detected) heteronuclear multiple-quantum coherence (HMQC) of loteprednol etabonate were reported and interpreted. All the H-1 NMR and C-13 NMR chemical shifts were assigned by means of H-1-H-1 COSY and HMQC. The chemical structure of the main characteristic fragmentations, pi --> pi * electron transition, and the vibrations of functional groups of the compound were discussed. The molecular structure of loteprednol etabonate has been identified.

关 键 词：氯替泼诺 特征吸收峰 不饱和 质谱 MS IR NMR 电子跃迁能 共轭体系 碎片 

分 类 号：TQ463[化学工程—制药化工]