云南石仙桃中酚类成分的研究  

Study on phenolic constituents of Pholidota yunnanensis

作　　者：毕志明[1] 王峥涛[1] 徐珞珊[1] 徐国钧[1] 

机构地区：[1]中国药科大学生药学研究室,江苏南京210038

出　　处：《中国药学杂志》2005年第4期255-258,共4页Chinese Pharmaceutical Journal

基　　金：国家自然科学基金资助项目 (3 0 17114 4)

摘　　要：目的　分离鉴定云南石仙桃中的酚类成分。方法　 95 %乙醇提取 ,硅胶柱色谱分离 ,用UV ,IR ,MS ,1H NMR ,13 C NMR和HMBC等方法确定结构。结果　分得 4个酚类成分 ,分别为eulophiol(Ⅰ ) ,lusianthridin(Ⅱ ) ,densiflorolB(Ⅲ )和batatasin Ⅲ (Ⅳ ) ,以及 4个其他类型的化合物 3,5 二甲氧基 4 羟基苯丙酮 (3,5 dimethoxy 4 hydroxypropiophenone ,V) ;(2 4R) 6 β hydroxy 2 4 ethyl cholest 4 en 3 one(VI) ;5α ,8α epidioxy 2 4 (R) methylcholesta 6 ,2 2 dion 3β ol(Ⅶ )和胡萝卜苷 (daucosterol,Ⅷ )。 结论　以上化合物均为首次从石仙桃属植物中分离得到。OBJECTIVE: To isolate and identify the phenolic constituents from Pholidota yunnanensis Rolfe. METHODS: The chromatography on silica gel was used for the isolation and purification of the constituents. The structures were determined by UV, IR, MS, 1H-NMR, 13C-NMR and HMBC spectral analyses. RESULTS: Four phenolic constituents and four other compounds were obtained and identified as following: eulophiol(I); lusianthridin(VI); densiflorol B(III); batatasin-III (IV); 3,5-dimethoxy-4-hydroxypropiophenone(V); (24R)-6β-hydroxy-24-ethyl-cholest-4-en-3-one(VI), 5α, 8α-epidioxy-24(R)-methylcholesta-6; 22-dion-3β-ol(1) and daucosterol(1). CONCLUSION: All above compounds were isolated from Genus Pholidota for the first time. The 13C-NMR data of compound I and II were reported for the first time.

关 键 词：云南石仙桃 兰科 酚类成分 

分 类 号：R284.2[医药卫生—中药学]