慢性粒细胞白血病骨髓组织学变异的探讨  

Investigation on Bone Marrow Histology of CGL

作　　者：张世蔚[1] 陈炳珍[1] 康小强 

机构地区：[1]同济医科大学血液病研究所

出　　处：《同济医科大学学报》1989年第5期301-303,共3页Acta Universitatis Medicinae Tongji

摘　　要：本文报道16例慢性粒细胞白血病(CGL)骨髓活检组织学变异的结果,其中CGL慢性期初治6例,复治4例;CGL急变4例和完全缓解2例。各期骨髓组织学变化与细胞成分和造血细胞过度增生有关。急变期可出现骨小梁紊乱、水肿和坏死等。骨髓细胞学检查2例完全缓解,骨髓组织学检查仅1例完全缓解。纤维组织增生在各期均可发生,完全缓解时似可恢复正常,增生是病情进展和预后不良的指征。The present article reported on bone marrow histological studies of 16 cases of CGL, of which 6 were untreated, 4 were treated, 2 were in complete remission and 4 underwent acute transformation. It was found that the changes of bone marrow histology in any stage of CGL are related to bone marrow hemopoietic component and their proliferative degree. For instance in the stage of CGL acute transformation, the disturbance of trabecular bone, edema and necrosis, etc. could be seen, while 2 cases of CGL were diagnosed as complete remission by cytology, only one was so by bone marrow biopsy. Fibrosis could be observed in any stage of the disease. However it could disappear when the disease underwent complete remission. Therefore the increasing fibrosis can serve as an indicator of the development and prognosis of the disease.

关 键 词：白血病 骨髓 活组织检查 组织学 

分 类 号：R733.720.2[医药卫生—肿瘤]