复方丹参与硫普罗宁抗肝纤维化的临床研究  

Clinical Study on Salvia Miltiorrhiza and Tiopronin for Fibrosis

作　　者：黄宗清[1] 冯秀琼[1] 叶润光[1] 

机构地区：[1]广西北海市人民医院消化内科,广西北海536000

出　　处：《广西中医学院学报》2005年第1期5-7,共3页Journal of Guangxi Traditional Chinese Medical University

摘　　要：[目的 ]观察复方丹参、硫普罗宁单用及合用对肝纤维化的影响。 [方法 ]复方丹参 +硫普罗宁治疗组、复方丹参治疗组、硫普罗宁治疗组各 4 0例 ,分别静滴复方丹参 2 0ml和 /或硫普罗宁 0 2g ,qd ,共 8周。对照组 30例 ,予一般护肝治疗。[结果 ]各组治疗后肝功能、肝纤维化指标均有不同程度好转 ,含丹参治疗组肝纤维化指标好转与硫普罗宁组及对照组比较差异显著 (P <0 0 5 ) ,且联合用药组优于单用组。 [结论 ]复方丹参与硫普罗宁均有抗肝纤维化的作用 ,且两者合用能提高抗肝纤维化的效应。ObjectiveTo observe the effect of salvia miltiorrhiza(SM) and tiopronin(TIO) for hepatic fibrosis.[Methods]There were forty patients each group: SM+TIO group(M32,F8,age 38±11.5a);SM group(M31,F9,age 40±12a);TIO group(M31,F9,age 38±12a). They received SM 20ml/d and/or TIO 0.2g/d, respectively for 8 weeks. The control group(M22,P8,age 39±13a) received the universal treatment.[Results]The liver function and serum parameters of fibrosis were improved in all groups. The chance of serum parameters of fibrosis in SM+TIO group and SM group were significantly better than that of the TIO group and control group,and the combination group was better than the other groups.[Conclusion]SM and TIO both had effect of anti-fibrosis and the combination of them can promote the effect.

关 键 词：复方丹参 硫普罗宁 肝纤维化 

分 类 号：R575[医药卫生—消化系统]