癫痫患儿血清中自身抗体的初步研究  

Preliminary study on autoantibodies in serum of epilepsy children

作　　者：宿丽娟[1] 冯刚[1] 王贞 迟婉莉[1] 杨静波[1] 张雅娟[1] 

机构地区：[1]吉化集团总医院,132022 [2]青岛市儿童医院

出　　处：《中国妇幼保健》2005年第6期750-751,共2页Maternal and Child Health Care of China

摘　　要：目的: 观察癫痫 (Epilepsy, EP) 患儿各种自身抗体水平, 从而探讨该病的发病与自身免疫的关系。方法: 抗核抗体 (Antinuclearantibodies, ANA) 测定采用间接免疫荧光法; 抗心磷脂抗体 (Anticardiolipinantibodies, ACA) 和抗谷氨酸脱羧酶抗体 (Autoantibodiestoglutamicaciddecarboxylase, GAD-A) 测定采用ELISA法。结果: 56例EP患儿血清中ANA、ACA和GAD-A阳性检出率分别为 46 .4%、30 4%和 21 .4%, 48例对照组血清中ANA、ACA和GAD-A检出率分别为 0、4. 2%和2. 1%, 患儿ANA、ACA和GAD-A的阳性检出率与正常对照相比差别均有显著性 (P<0 .01)。病例组与对照组 3种自身抗体的总阳性率分别为 51 .8%和 6. 3%, 明显高于对照组, 差别有显著性 (P<0 .01), 其中存在 2种以上自身抗体者占 28. 6%。结论: 癫痫存在自身免疫倾向, 自身抗体在EP发病机制中可能起重要作用。Objective:To investigate the relationship between epilepsy (EP) and autoantibodies.Methods:The antinuclear antibodies (ANA) was detected with indirect immunofluorescenee (IIF),anticardiolipin antibodies(ACA) and autoantibodies to glutamic acid decarboxylase (GAD-A)were detected with enzyme-linked immunosorbent assay (ELISA).Results:The positive rates of ANA ,ACA and GAD-A in EP children were 46.4%, 30.4% and 21.4% respectively. The positive rates of ANA, ACA and GAD-A in normal control were 0, 4.2%and 2.1% respectively. The positive rates of EP children were higher than that of normal control.The total positive rate of autoantibodies in EP children ( 51.8%) was higher than that of normal control (6.3%) (P<0.01 ) .The positive rate of more than 2 kinds of autoantibodies was 28.6%.Conclusion:There is a tendency of antoimmunity in the patients with epilepsy .Autoantibodies may play an important role in the pathogenisis of epilepsy.

关 键 词：癫痫 ANA ACA GAD—A 

分 类 号：R742.1[医药卫生—神经病学与精神病学]