不典型慢性粒细胞白血病血液学特征分析  

The Analysis of Atypical Chronic Myelogenous Leukemia

作　　者：孔晋星[1] 石洪琼[1] 晋臻[1] 

机构地区：[1]昆明医学院第一附属医院检验科,昆明650032

出　　处：《昆明医学院学报》2005年第1期76-78,共3页Journal of Kunming Medical College

摘　　要：目的 :探讨不典型慢性粒细胞白血病的诊断 .方法 :对比分析 12例不典型慢性粒细胞白血病和2 3例典型慢性粒细胞白血病的临床表现和血液细胞学特征 .结果 :不典型慢性粒细胞白血病发病年龄较大 ,多数患者无贫血 ,血小板轻度增高 ,脾大不明显 ,外周血中性粒细胞碱性磷酸酶积分稍减低或正常 ,Ph染色体阴性 ,PCR检测阴性 .结论 :不典型慢性粒细胞白血病诊断必须结合临床动态观察 ,若随病程延长 ,病情加重 ,其他治疗无效者 ,应考虑本病 .Objective: To investigate the diagnosis of atypical chronic myelogenous leukemia.Methods: Through the comparison between atypical chronic myelogenous leukemia (12 cases) and typical chronic myelogenous leukemia (23 cases), we can find out that atypical chronic myelogenous leukemia was different from typical chronic myelogenous leukemia in clinical characteristics and morphology features.Results:First of all,the patients' age is always old.In most cases, there was not anemia but platelet was slightly higher than the normal, swelling of spleen was not unconspicuous, and the neutrophil alkaline phosphatase score was normal or slightly decreased.Philadelphia (Ph) chromosome was undetectable by polymerase chain reaction (PCR) as well.Conclusion: To diagnose this disease, the course of disease must be observed in succession which is aggravated along with the time passing and the other therapies are invalid.

关 键 词：不典型 慢性粒细胞白血病 诊断 血液学特征 阴性 治疗 病情加重 应考 结论 目的 

分 类 号：R733[医药卫生—肿瘤] R542[医药卫生—临床医学]